The KCNJ6 Polyclonal Antibody (CAB9935) is a valuable tool for researchers studying KCNJ6, a potassium channel protein involved in neuronal excitability and neurotransmitter release. This antibody, raised in rabbits, exhibits high specificity and sensitivity for detecting KCNJ6 in human samples, making it ideal for use in Western blot applications.KCNJ6, also known as the GIRK2 potassium channel, plays a crucial role in regulating the electrical activity of neurons and modulating synaptic transmission. Dysregulation of KCNJ6 has been implicated in various neurological disorders, including epilepsy, Parkinson's disease, and addiction.
By using the KCNJ6 Polyclonal Antibody, researchers can gain insights into the expression and function of KCNJ6 in different cell types and tissues, providing valuable data for studies in neuroscience and drug development. Understanding the role of KCNJ6 in neuronal signaling pathways is essential for developing targeted therapies for neurological conditions associated with aberrant potassium channel activity.
Antibody Name:
Anti-KCNJ6 Antibody
Antibody SKU:
CAB9935
Antibody Size:
20uL, 50uL, 100uL
Application:
WB
Reactivity:
Human, Mouse
Host Species:
Rabbit
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human KCNJ6 (NP_002231.1).
Application:
WB
Recommended Dilution:
WB 1:500 - 1:2000
Reactivity:
Human, Mouse
Positive Samples:
NIH/3T3, Mouse brain
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human KCNJ6 (NP_002231.1).
Purification Method:
Affinity purification
Storage Buffer:
Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
This gene encodes a member of the G protein-coupled inwardly-rectifying potassium channel family of inward rectifier potassium channels. This type of potassium channel allows a greater flow of potassium into the cell than out of it. These proteins modulate many physiological processes, including heart rate in cardiac cells and circuit activity in neuronal cells, through G-protein coupled receptor stimulation. Mutations in this gene are associated with Keppen-Lubinsky Syndrome, a rare condition characterized by severe developmental delay, facial dysmorphism, and intellectual disability.
UniProt Protein Function:
This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
NCBI Summary:
This gene encodes a member of the G protein-coupled inwardly-rectifying potassium channel family of inward rectifier potassium channels. This type of potassium channel allows a greater flow of potassium into the cell than out of it. These proteins modulate many physiological processes, including heart rate in cardiac cells and circuit activity in neuronal cells, through G-protein coupled receptor stimulation. Mutations in this gene are associated with Keppen-Lubinsky Syndrome, a rare condition characterized by severe developmental delay, facial dysmorphism, and intellectual disability. [provided by RefSeq, Apr 2015]
