Human UPRT Recombinant Protein (RPPB2410)
- SKU:
- RPPB2410
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- UPRT
- Synonyms:
- Uracil phosphoribosyltransferase homolog
- Uracil phosphoribosyltransferase (FUR1) homolog (Scerevisiae)
- FUR1
- Uracil Phosphoribosyltransferase
- Source:
- Escherichia Coli
- Uniprot:
- Q96BW1
Frequently bought together:
Description
| Product Name: | Human UPRT Recombinant Protein |
| Product Code: | RPPB2410 |
| Size: | 10µg |
| Species: | Human |
| Target: | UPRT |
| Synonyms: | Uracil phosphoribosyltransferase homolog, Uracil phosphoribosyltransferase (FUR1) homolog (S.cerevisiae), FUR1, Uracil Phosphoribosyltransferase, RP11-311P8.3, UPP, UPRT, UPRTase, UMP pyrophosphorylase, uprt. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | UPRT protein solution (0. 5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMATELQC PDSMPCHNQQ VNSASTPSPE QLRPGDLILD HAGGNRASRA KVILLTGYAH SSLPAELDSG ACGGSSLNSE GNSGSGDSSS YDAPAGNSFL EDCELSRQIG AQLKLLPMND QIRELQTIIR DKTASRGDFM FSADRLIRLV VEEGLNQLPY KECMVTTPTG YKYEGVKFEK GNCGVSIMRS GEAMEQGLRD CCRSIRIGKI LIQSDEETQR AKVYYAKFPP DIYRRKVLLM YPILSTGNTV IEAVKVLIEH GVQPSVIILL SLFSTPHGAK SIIQEFPEIT ILTTEVHPVA PTHFGQKYFG TD |
UPRT is a uracil phosphoribosyltransferase, that catalyzes the alteration of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP). This reaction is a significant part of nucleotide metabolism, specifically the pyrimidine salvage pathway. UPRT is restricted to the nucleus and cytoplasm and is a possible target for rational design of drugs to cure cancer and parasitic infections.
UPRT Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 332 amino acids (1-309 a.a) and having a molecular mass of 36.2kDa.UPRT is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | UPRT: an enzyme which catalyzes the conversion of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP). This reaction is an important part of nucleotide metabolism, specifically the pyrimidine salvage pathway. The enzyme localizes to the nucleus and cytoplasm. The protein is a potential target for rational design of drugs to treat parasitic infections and cancer. [provided by RefSeq, Nov 2009]Protein type: EC 2.4.2.9; Transferase; Nucleotide Metabolism - pyrimidineChromosomal Location of Human Ortholog: Xq13.3Cellular Component: cytosolMolecular Function: protein binding; uridine kinase activityBiological Process: pyrimidine base metabolic process; pyrimidine nucleoside salvage |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes uracil phosphoribosyltransferase, which catalyzes the conversion of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP). This reaction is an important part of nucleotide metabolism, specifically the pyrimidine salvage pathway. The enzyme localizes to the nucleus and cytoplasm. The protein is a potential target for rational design of drugs to treat parasitic infections and cancer. [provided by RefSeq, Nov 2009] |
| UniProt Code: | Q96BW1 |
| NCBI GenInfo Identifier: | 74751783 |
| NCBI Gene ID: | 139596 |
| NCBI Accession: | Q96BW1.1 |
| UniProt Secondary Accession: | Q96BW1,Q5JRL1, Q5JRL3, Q68DN0, Q96MW2 |
| UniProt Related Accession: | Q96BW1 |
| Molecular Weight: | 19,056 Da |
| NCBI Full Name: | Uracil phosphoribosyltransferase homolog |
| NCBI Synonym Full Names: | uracil phosphoribosyltransferase homolog |
| NCBI Official Symbol: | UPRT |
| NCBI Official Synonym Symbols: | UPP; FUR1 |
| NCBI Protein Information: | uracil phosphoribosyltransferase homolog |
| UniProt Protein Name: | Uracil phosphoribosyltransferase homolog |
| UniProt Synonym Protein Names: | |
| Protein Family: | Uracil phosphoribosyltransferase |
| UniProt Gene Name: | UPRT |
| UniProt Entry Name: | UPP_HUMAN |
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