Human UBL4A Recombinant Protein (RPPB5068)
- SKU:
- RPPB5068
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- UBL4A
- Synonyms:
- Ubiquitin-like protein 4A
- Ubiquitin-like protein GDX
- UBL4A
- DXS254E
- Source:
- Escherichia Coli
- Uniprot:
- P11441
Description
| Product Name: | Human UBL4A Recombinant Protein |
| Product Code: | RPPB5068 |
| Size: | 20µg |
| Species: | Human |
| Target: | UBL4A |
| Synonyms: | Ubiquitin-like protein 4A, Ubiquitin-like protein GDX, UBL4A, DXS254E, GDX, UBL4, G6PD, GET5, MDY2, TMA24, DX254E. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | UBL4A protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 10% glycerol and 100mM NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MQLTVKALQG RECSLQVPED ELVSTLKQLV SEKLNVPVRQ QRLLFKGKAL ADGKRLSDYS IGPNSKLNLV VKPLEKVLLE EGEAQRLADS PPPQVWQLIS KVLARHFSAA DASRVLEQLQ RDYERSLSRL TLDDIERLAS RFLHPEVTET MEKGFSKLEH HHHHH |
Ubiquitin-Like 4A (UBL4A) contains one ubiquitin-like domain. UBL4A is a component of the BAT3 complex, which is a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. Post-translational modification by ubiquitin and ubiquitin-related proteins plays decisive roles in protein degradation and in regulation of crucial cellular processes. Due to the fact that in mammals, transcription halts during late spermiogenesis as a result of compaction of the spermatid genome, which creates a special need for robust post-transcriptional regulation.
UBL4A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 165 amino acids (1-157 a.a.) and having a molecular mass of 18.8kDa.UBL4A is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | UBL4A: Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteins capture by ASNA1/TRC40: it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting. |
| UniProt Protein Details: | Protein type:Ubiquitin-like modifier Chromosomal Location of Human Ortholog: Xq28 Cellular Component: cytosol Molecular Function:protein binding; small conjugating protein ligase activity Biological Process: transport; protein modification process |
| UniProt Code: | P11441 |
| NCBI GenInfo Identifier: | 136662 |
| NCBI Gene ID: | 8266 |
| NCBI Accession: | P11441.1 |
| UniProt Secondary Accession: | P11441,Q5HY80, |
| UniProt Related Accession: | P11441 |
| Molecular Weight: | 157 |
| NCBI Full Name: | Ubiquitin-like protein 4A |
| NCBI Synonym Full Names: | ubiquitin-like 4A |
| NCBI Official Symbol: | UBL4A |
| NCBI Official Synonym Symbols: | GDX; G6PD; GET5; MDY2; UBL4; TMA24; DX254E; DXS254E |
| NCBI Protein Information: | ubiquitin-like protein 4A; ubiquitin-like 4; ubiquitin-like protein GDX |
| UniProt Protein Name: | Ubiquitin-like protein 4A |
| UniProt Synonym Protein Names: | Ubiquitin-like protein GDX |
| Protein Family: | Ubiquitin-like protein |
| UniProt Gene Name: | UBL4A |
| UniProt Entry Name: | UBL4A_HUMAN |
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