Human TTC1 Recombinant Protein (RPPB5035)
- SKU:
- RPPB5035
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- TTC1
- Synonyms:
- Tetratricopeptide repeat protein 1
- TPR repeat protein 1
- TTC1
- TPR1
- Source:
- Escherichia Coli
- Uniprot:
- Q99614
Description
| Product Name: | Human TTC1 Recombinant Protein |
| Product Code: | RPPB5035 |
| Size: | 20µg |
| Species: | Human |
| Target: | TTC1 |
| Synonyms: | Tetratricopeptide repeat protein 1, TPR repeat protein 1, TTC1, TPR1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | TTC1 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1M NaCl and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMGEKSE NCGVPEDLLN GLKVTDTQEA ECAGPPVPDP KNQHSQSKLL RDDEAHLQED QGEEECFHDC SASFEEEPGA DKVENKSNED VNSSELDEEY LIELEKNMSD EEKQKRREES TRLKEEGNEQ FKKGDYIEAE SSYSRALEMC PSCFQKERSI LFSNRAAARM KQDKKEMAIN DCSKAIQLNP SYIRAILRRA ELYEKTDKLD EALEDYKSIL EKDPSIHQAR EACMRLPKQI EERNERLKEE MLGKLKDLGN LVLRPFGLST ENFQIKQDSS TGSYSINFVQ NPNNNR |
Tetratricopeptide repeat protein 1 (TTC1) is comprised of 292 amino acids with 3 TPR motifs, such as a Galpha16-binding protein. This interaction is confirmed both in vitro and in transfected mammalian cells, where TTC1 also binds to a number of other Galpha proteins. TTC1 interacts with Ha-Ras especially in its active form. TTC1 also interacts with the GAP domain of NF1.
TTC1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 316 amino acids (1-292 a.a) and having a molecular mass of 36.1kDa (Molecular weight on SDS-PAGE will appear higher).TTC1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TTC1: Interacts with the GAP domain of NF1. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 5q33.3 Cellular Component: peroxisomal membrane; cytoplasm Molecular Function:protein binding; unfolded protein binding Biological Process: protein folding |
| NCBI Summary: | This gene encodes a protein that belongs to the tetratrico peptide repeat superfamily of proteins. The encoded protein plays a role in protein-protein interactions, and binds to the Galpha subunit of G protein-coupled receptors to activate the Ras signaling pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] |
| UniProt Code: | Q99614 |
| NCBI GenInfo Identifier: | 543173164 |
| NCBI Gene ID: | 7265 |
| NCBI Accession: | NP_001269429.1 |
| UniProt Secondary Accession: | Q99614,Q9BVT3, B2RCT2, D3DQJ8, |
| UniProt Related Accession: | Q99614 |
| Molecular Weight: | 33,526 Da |
| NCBI Full Name: | tetratricopeptide repeat protein 1 |
| NCBI Synonym Full Names: | tetratricopeptide repeat domain 1 |
| NCBI Official Symbol: | TTC1 |
| NCBI Official Synonym Symbols: | TPR1 |
| NCBI Protein Information: | tetratricopeptide repeat protein 1; TPR repeat protein 1 |
| UniProt Protein Name: | Tetratricopeptide repeat protein 1 |
| UniProt Gene Name: | TTC1 |
| UniProt Entry Name: | TTC1_HUMAN |
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