Description
| Product Name: | Human TP53AIP1 Recombinant Protein |
| Product Code: | RPPB4986 |
| Size: | 20µg |
| Species: | Human |
| Target: | TP53AIP1 |
| Synonyms: | p53-regulated apoptosis-inducing protein 1, Tumor ProteinP53 Regulated Apoptosis Inducing Protein 1, TP53AIP1, p53AIP1, P53-regulatedapoptosis-inducing protein 1 isoform a, TPIP1, P53AIP1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The TP53AIP1 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4M Urea. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHHSSGLVPRGSHMGSSSEASFR SAQASCSGAR RQGLGRGDQN LSVMPPNGRA QTHTPGWVSD PLVLGAQVHG GCRGIEALSV SSGSWSSATVWILTGLGLGL SRPFLPGATV LRDRPLGSAF ELSYDQKKAP LRLQ |
Tumor Protein P53 Regulated Apoptosis Inducing Protein 1 (TP53AIP1) is expressed mainly in the thymus, and is localized to the mitochondrion. p53 induces TP53AIP1 production which then mediates p53- dependent apoptosis. Alternatively spliced transcript variants encoding diverse isoforms are known for TP53AIP1.
TP53AIP1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 144 amino acids (1-124) and having a molecular mass of 15kDa.TP53AIP1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | p53AIP1: May play an important role in mediating p53/TP53- dependent apoptosis. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Mitochondrial; Apoptosis Chromosomal Location of Human Ortholog: 11q24 Cellular Component: mitochondrion Biological Process: apoptosis |
| NCBI Summary: | This gene is specifically expressed in the thymus, and encodes a protein that is localized to the mitochondrion. The expression of this gene is inducible by p53, and it is thought to play an important role in mediating p53-dependent apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011] |
| UniProt Code: | Q9HCN2 |
| NCBI GenInfo Identifier: | 74718882 |
| NCBI Gene ID: | 63970 |
| NCBI Accession: | Q9HCN2.1 |
| UniProt Secondary Accession: | Q9HCN2,Q6NT40, Q7Z6F7, Q9HCN0, Q9HCN1, |
| UniProt Related Accession: | Q9HCN2 |
| Molecular Weight: | 124 |
| NCBI Full Name: | p53-regulated apoptosis-inducing protein 1 |
| NCBI Synonym Full Names: | tumor protein p53 regulated apoptosis inducing protein 1 |
| NCBI Official Symbol: | TP53AIP1�� |
| NCBI Official Synonym Symbols: | P53AIP1�� |
| NCBI Protein Information: | p53-regulated apoptosis-inducing protein 1 |
| UniProt Protein Name: | p53-regulated apoptosis-inducing protein 1 |
| Protein Family: | p53-regulated apoptosis-inducing protein |
| UniProt Gene Name: | TP53AIP1�� |
| UniProt Entry Name: | TPIP1_HUMAN |
