Human TMOD3 Recombinant Protein (RPPB4974)
- SKU:
- RPPB4974
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- TMOD3
- Synonyms:
- Tropomodulin-3
- Ubiquitous tropomodulin
- U-Tmod
- TMOD3
- Source:
- Escherichia Coli
- Uniprot:
- Q9NYL9
Description
| Product Name: | Human TMOD3 Recombinant Protein |
| Product Code: | RPPB4974 |
| Size: | 10µg |
| Species: | Human |
| Target: | TMOD3 |
| Synonyms: | Tropomodulin-3, Ubiquitous tropomodulin, U-Tmod, TMOD3, UTMOD. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | TMOD3 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 80.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMALPFR KDLEKYKDLD EDELLGNLSE TELKQLETVL DDLDPENALL PAGFRQKNQT SKSTTGPFDR EHLLSYLEKE ALEHKDREDY VPYTGEKKGK IFIPKQKPVQ TFTEEKVSLD PELEEALTSA SDTELCDLAA ILGMHNLITN TKFCNIMGSS NGVDQEHFSN VVKGEKILPV FDEPPNPTNV EESLKRTKEN DAHLVEVNLN NIKNIPIPTL KDFAKALETN THVKCFSLAA TRSNDPVATA FAEMLKVNKT LKSLNVESNF ITGVGILALI DALRDNETLA ELKIDNQRQQ LGTAVELEMA KMLEENTNIL KFGYQFTQQG PRTRAANAIT KNNDLVRKRR VEGDHQ |
Tropomodulin 3 (TMOD3) is a member of the tropomodulin family. TMOD3 prevents the elongation and depolymerization of the actin filaments at the pointed end. Actin cytoskeleton regulation by filament capping proteins is essential to many dynamic cellular functions. TMOD3 functions as a negative regulator of cell migration; nevertheless the processes behind its cellular functions are unknown. The Tmod/TM complex influences the formation of the short actin protofilament, which sequentially outlines the geometry of the membrane skeleton.
TMOD3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 376 amino acids (1-352 a.a) and having a molecular mass of 42kDa.TMOD3 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TMOD3: Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. Belongs to the tropomodulin family. |
| UniProt Protein Details: | Protein type:Cytoskeletal; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 15q21.1-q21.2 Cellular Component: striated muscle thin filament Molecular Function:actin binding; tropomyosin binding Biological Process: erythrocyte development; myofibril assembly; muscle contraction; actin filament organization; pointed-end actin filament capping |
| UniProt Code: | Q9NYL9 |
| NCBI GenInfo Identifier: | 23396884 |
| NCBI Gene ID: | 29766 |
| NCBI Accession: | Q9NYL9.1 |
| UniProt Related Accession: | Q9NYL9 |
| Molecular Weight: | |
| NCBI Full Name: | Tropomodulin-3 |
| NCBI Synonym Full Names: | tropomodulin 3 |
| NCBI Official Symbol: | TMOD3 |
| NCBI Official Synonym Symbols: | UTMOD |
| NCBI Protein Information: | tropomodulin-3 |
| UniProt Protein Name: | Tropomodulin-3 |
| UniProt Synonym Protein Names: | Ubiquitous tropomodulin; U-Tmod |
| Protein Family: | Tropomodulin |
| UniProt Gene Name: | TMOD3 |
| UniProt Entry Name: | TMOD3_HUMAN |
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