Human TBCEL Recombinant Protein (RPPB4919)
- SKU:
- RPPB4919
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- TBCEL
- Synonyms:
- Tubulin Folding Cofactor E-Like
- E-Like
- LRRC351
- Leucine Rich Repeat Containing Catastrophin
- Source:
- Escherichia Coli
- Uniprot:
- Q5QJ74
Description
| Product Name: | Human TBCEL Recombinant Protein |
| Product Code: | RPPB4919 |
| Size: | 20µg |
| Species: | Human |
| Target: | TBCEL |
| Synonyms: | Tubulin Folding Cofactor E-Like, E-Like, LRRC351, Leucine Rich Repeat Containing Catastrophin, Tubulin-Specific Chaperone E-Like. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The TBCEL solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0) 0.15M NaCl, 20% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMDQPSGR SFMQVLCEKY SPENFPYRRG PGMGVHVPAT PQGSPMKDRL NLPSVLVLNS CGITCAGDEK EIAAFCAHVS ELDLSDNKLE DWHEVSKIVS NVPQLEFLNL SSNPLNLSVL ERTCAGSFSG VRKLVLNNSK ASWETVHMIL QELPDLEELF LCLNDYETVS CPSICCHSLK LLHITDNNLQ DWTEIRKLGV MFPSLDTLVL ANNHLNAIEE PDDSLARLFP NLRSISLHKS GLQSWEDIDK LNSFPKLEEV RLLGIPLLQP YTTEERRKLV IARLPSVSKL NGSVVTDGER EDSERFFIRY YVDVPQEEVP FRYHELITKY GKLEPLAEVD LRPQSSAKVE VHFNDQVEEM SIRLDQTVAE LKKQLKTLVQ LPTSNMLLYY FDHEAPFGPE EMKYSSRALH SFGIRDGDKI YVESKTK |
TBCEL, is a factor that is in charge of the microtubule cytoskeleton in determining cell behavior. TBCEL plays a role as a regulator of tubulin stability. While widely expressed in testis, TBCEL is also present in several tissues at a much lower level. TBCEL comprises of seven LRR (leucine-rich) repeats, one LRRCT domain and one ubiquitin-like domain. The gene that translates TBCEL consists of 66,704 bases and maps to human chromosome 11q23.3. Chromosome 11 houses over 1,400 genes and consist of nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that map to chromosome 11.
TBCEL Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 447 amino acids and having a molecular mass of 50.6kDa. The TBCEL is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | LRRC35: Acts as a regulator of tubulin stability.Chromosomal Location of Human Ortholog: 11q23.3Molecular Function: protein binding |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q5QJ74 |
| NCBI GenInfo Identifier: | 215273924 |
| NCBI Gene ID: | 219899 |
| NCBI Accession: | Q5QJ74.2 |
| UniProt Secondary Accession: | Q5QJ74,Q0VAN6 |
| UniProt Related Accession: | Q5QJ74 |
| Molecular Weight: | 48,195 Da |
| NCBI Full Name: | Tubulin-specific chaperone cofactor E-like protein |
| NCBI Synonym Full Names: | tubulin folding cofactor E like |
| NCBI Official Symbol: | TBCEL |
| NCBI Official Synonym Symbols: | El; LRRC35 |
| NCBI Protein Information: | tubulin-specific chaperone cofactor E-like protein |
| UniProt Protein Name: | Tubulin-specific chaperone cofactor E-like protein |
| UniProt Synonym Protein Names: | Leucine-rich repeat-containing protein 35 |
| Protein Family: | Tubulin-specific chaperone cofactor E-like protein |
| UniProt Gene Name: | TBCEL |
| UniProt Entry Name: | TBCEL_HUMAN |
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