Human TARS Recombinant Protein (RPPB2306)
- SKU:
- RPPB2306
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- TARS
- Synonyms:
- Threonyl-tRNA synthetase cytoplasmic
- EC 6113
- Threonine-tRNA ligase
- ThrRS
- Source:
- Sf9 Insect cells
- Uniprot:
- P26639
Description
| Product Name: | Human TARS Recombinant Protein |
| Product Code: | RPPB2306 |
| Size: | 20µg |
| Species: | Human |
| Target: | TARS |
| Synonyms: | Threonyl-tRNA synthetase cytoplasmic, EC 6.1.1.3, Threonine-tRNA ligase, ThrRS, MGC9344, PL-7, TARS. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | TARS is supplied in 20mM HEPES buffer pH-8, 200mM sodium chloride, and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Purity: | TARS purity is greater than 90% as determined by SDS-PAGE. |
Threonyl-tRNA Synthetase is a member of the aminoacyl-tRNA synthetase family, key enzymes of protein biosynthesis which charge tRNA molecules with the respective amino acids. This 83 kDa protein is an autoantigen recognized by PL-7 antibodies which occur in a subset of patients with polymyositis and dermatomyositis. Preliminary data suggest that PL-7 antibodies (similar to Jo-1 antibodies) indicate an increased risk for lung involvement, but this needs to be confirmed for a larger number of cases.
TARS Human Recombinant produced in SF9 is a glycosylated, polypeptide chain having a molecular mass of 83,312 Dalton. TARS is expressed with a -6xHis tag and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TARS: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase family [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Protein type:EC 6.1.1.3; Translation; Ligase Chromosomal Location of Human Ortholog: 5p13.2 Cellular Component: cytoplasm; cytosol; actin cytoskeleton Molecular Function:threonine-tRNA ligase activity; protein homodimerization activity; ATP binding Biological Process: tRNA aminoacylation for protein translation; translation; threonyl-tRNA aminoacylation; gene expression |
| NCBI Summary: | Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase family [provided by RefSeq, Jul 2008] |
| UniProt Code: | P26639 |
| NCBI GenInfo Identifier: | 60267755 |
| NCBI Gene ID: | 6897 |
| NCBI Accession: | P26639.3 |
| UniProt Related Accession: | P26639 |
| Molecular Weight: | ~ 83kDa |
| NCBI Full Name: | Threonine--tRNA ligase 1, cytoplasmic |
| NCBI Synonym Full Names: | threonyl-tRNA synthetase 1 |
| NCBI Official Symbol: | TARS1 |
| NCBI Official Synonym Symbols: | TARS; TTD7; ThrRS |
| NCBI Protein Information: | threonine--tRNA ligase 1, cytoplasmic |
| UniProt Protein Name: | Threonine--tRNA ligase, cytoplasmic |
| UniProt Synonym Protein Names: | Threonyl-tRNA synthetase; ThrRS |
| UniProt Gene Name: | TARS |
| UniProt Entry Name: | SYTC_HUMAN |
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