Human TACSTD2 Recombinant Protein (RPPB4898)
- SKU:
- RPPB4898
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- TACSTD2
- Synonyms:
- Tumor-Associated Calcium Signal Transducer 2
- MembraneComponent Chromosome 1 Surface Marker 1
- Pancreatic Carcinoma Marker ProteinGA733-1
- Cell Surface Glycoprotein Trop-2
- Source:
- Sf9 Insect cells
- Uniprot:
- P09758
Description
| Product Name: | Human TACSTD2 Recombinant Protein |
| Product Code: | RPPB4898 |
| Size: | 10µg |
| Species: | Human |
| Target: | TACSTD2 |
| Synonyms: | Tumor-Associated Calcium Signal Transducer 2,MembraneComponent Chromosome 1 Surface Marker 1, Pancreatic Carcinoma Marker ProteinGA733-1,Cell Surface Glycoprotein Trop-2, GA733-1,TROP2, M1S1,40kD Glycoprotein, Identified By Monoclonal Antibody GA733,MembraneComponent, Chromosome 1, Surface Marker 1, Gastrointestinal Tumor-AssociatedAntigen GA7331,Pancreatic Carcinoma Marker Protein GA7331,CellSurface Glycoprotein TROP2,Epithelial Glycoprotein-1TruncatedTACSTD2,GA7331,EGP-1,EGP1,GP50, TACSTD2. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | TACSTD2 protein solution (1mg/ml) contains Phosphate buffered saline (pH7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPQDNCTCP TNKMTVCSPD GPGGRCQCRA LGSGMAVDCS TLTSKCLLLK ARMSAPKNAR TLVRPSEHAL VDNDGLYDPD CDPEGRFKAR QCNQTSVCWC VNSVGVRRTD KGDLSLRCDE LVRTHHILID LRHRPTAGAF NHSDLDAELR RLFRERYRLH PKFVAAVHYE QPTIQIELRQNTSQKAAGDV DIGDAAYYFE RDIKGESLFQ GRGGLDLRVR GEPLQVERTL IYYLDEIPPK FSMKRLTHHH HHH |
Tumor-associated calcium signal transducer 2 (TACSTD2), is a member of to the EPCAM family. TACSTD2 is an intronless gene which encodes a carcinoma-associated antigen. TACSTD2 may act as a growth factor receptor and as a cell surface receptor that transduces calcium signals. Mutations of TACSTD2 have been associated with gelatinous drop-like corneal dystrophy.
TACSTD2 Human Recombinant produced in Sf9 Baculovirus cells is a single, non-glycosylated polypeptide chain containing 253 amino acids (31-274a.a) and having a molecular mass of 28.6kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa).TACSTD2 is fused to a 6 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TACSTD2: May function as a growth factor receptor. Defects in TACSTD2 are the cause of gelatinous drop-like corneal dystrophy (GDLD); also known as lattice corneal dystrophy type III. GDLD is an autosomal recessive disorder characterized by grayish corneal amyloid deposits that cause severe visual impairment. Belongs to the EPCAM family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 1p32 Cellular Component: basal plasma membrane; cytosol; extracellular space; integral to plasma membrane; lateral plasma membrane; membrane; nucleus Molecular Function:protein binding; receptor activity Biological Process: cell proliferation; cell surface receptor linked signal transduction; negative regulation of stress fiber formation Disease: Corneal Dystrophy, Gelatinous Drop-like |
| NCBI Summary: | This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009] |
| UniProt Code: | P09758 |
| NCBI GenInfo Identifier: | 160113102 |
| NCBI Gene ID: | 4070 |
| NCBI Accession: | P09758.3 |
| UniProt Secondary Accession: | P09758,Q15658, Q6FG48, Q7Z7Q4, Q96QD2, |
| UniProt Related Accession: | P09758 |
| Molecular Weight: | 35,709 Da |
| NCBI Full Name: | Tumor-associated calcium signal transducer 2 |
| NCBI Synonym Full Names: | tumor-associated calcium signal transducer 2 |
| NCBI Official Symbol: | TACSTD2 |
| NCBI Official Synonym Symbols: | EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1 |
| NCBI Protein Information: | tumor-associated calcium signal transducer 2 |
| UniProt Protein Name: | Tumor-associated calcium signal transducer 2 |
| UniProt Synonym Protein Names: | Cell surface glycoprotein Trop-2; Membrane component chromosome 1 surface marker 1; Pancreatic carcinoma marker protein GA733-1 |
| Protein Family: | Tumor-associated calcium signal transducer |
| UniProt Gene Name: | TACSTD2 |
| UniProt Entry Name: | TACD2_HUMAN |
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