Human SNRPF Recombinant Protein (RPPB4761)
- SKU:
- RPPB4761
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- SNRPF
- Synonyms:
- Sm-F
- Sm protein F
- snRNP-F
- SMF
- Source:
- Escherichia Coli
- Uniprot:
- P62306
Description
| Product Name: | Human SNRPF Recombinant Protein |
| Product Code: | RPPB4761 |
| Size: | 20µg |
| Species: | Human |
| Target: | SNRPF |
| Synonyms: | Sm-F, Sm protein F, snRNP-F, SMF, PBSCF, Small Nuclear Ribonucleoprotein Polypeptide F. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The SNRPF protein solution (1mg/1ml) is formulated in 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 1mM EDTA , and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MSLPLNPKPF LNGLTGKPVM VKLKWGMEYK GYLVSVDGYM NMQLANTEEY IDGALSGHLG EVLIRCNNVL YIRGVEEEEE DGEMRE |
SNRPF is a member of the snRNP Sm proteins family. There are at least seven isoforms, E, F, G, D1, D2, D3 and B/B. This type of common proteins have a crucial part in the biogenesis of the snRNPs. Moreover, they represent the major targets for the so-called anti-Sm auto-antibodies that are diagnostic for systemic lupus erythematosus (SLE). SNRPF assist in the cytoplasmic construction of the UsnRNPs by binding to aconserved Sm site on UsnRNA and forming a stable snRNP core complex.
SNRPF produced in E.Coli is a single, non-glycosylated polypeptide chain containing 106 amino acids (1-86a.a.) and having a molecular mass of 11.8kDa.SNRPF is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | snRNP F: Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Associated with snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; RNA splicing; Spliceosome Chromosomal Location of Human Ortholog: 12q23.1 Cellular Component: cytosol; nucleoplasm; small nuclear ribonucleoprotein complex; snRNP U1; spliceosome; U12-dependent spliceosome Molecular Function:protein binding; RNA binding Biological Process: histone mRNA metabolic process; nuclear import; nuclear mRNA splicing, via spliceosome; RNA splicing; spliceosomal snRNP biogenesis; termination of RNA polymerase II transcription |
| UniProt Code: | P62306 |
| NCBI GenInfo Identifier: | 61237391 |
| NCBI Gene ID: | 6636 |
| NCBI Accession: | P62306.1 |
| UniProt Secondary Accession: | P62306,Q15356, Q6IBQ1, Q6P4I0, A2VCR2, B2R498, |
| UniProt Related Accession: | P62306 |
| Molecular Weight: | 10kDa |
| NCBI Full Name: | Small nuclear ribonucleoprotein F |
| NCBI Synonym Full Names: | small nuclear ribonucleoprotein polypeptide F |
| NCBI Official Symbol: | SNRPF |
| NCBI Official Synonym Symbols: | SMF; Sm-F; snRNP-F |
| NCBI Protein Information: | small nuclear ribonucleoprotein F |
| UniProt Protein Name: | Small nuclear ribonucleoprotein F |
| UniProt Synonym Protein Names: | Sm protein F; Sm-F; SmF |
| UniProt Gene Name: | SNRPF |
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