Human SEC61B Recombinant Protein (RPPB4611)
- SKU:
- RPPB4611
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- SEC61B
- Synonyms:
- Protein transport protein Sec61 subunit beta
- SEC61B
- Sec61 Beta Subunit
- Protein Translocation Complex Beta
- Source:
- Escherichia Coli
- Uniprot:
- P60468
Description
| Product Name: | Human SEC61B Recombinant Protein |
| Product Code: | RPPB4611 |
| Size: | 10µg |
| Species: | Human |
| Target: | SEC61B |
| Synonyms: | Protein transport protein Sec61 subunit beta, SEC61B, Sec61 Beta Subunit, Protein Translocation Complex Beta, Protein Transport Protein SEC61 Beta Subunit, Sec61 Complex Beta Subunit. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | SEC61B protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 50% glycerol and 2mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMPGPTPS GTNVGSSGRS PSKAVAARAA GSTVRQRKNA SCGTRSAGRT TSAGTGGMWR FYTEDSPGLK VGP |
The Sec61 complex is the key component of the protein translocation apparatus of the ER (endoplasmic reticulum) membrane. Oligomers of the Sec61 complex construct a transmembrane channel where proteins are translocated across and incorporated into the ER membrane. This complex consists of 3 membrane proteins- alpha, beta, and gamma. The SEC61B gene encodes the beta-subunit protein. The Sec61 subunits are also detected in the post-ER compartment, suggesting that these proteins can get out of the ER and recycle back.
SEC61B Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 93 amino acids (1-70 a.a) and having a molecular mass of 9.4kDa.SEC61B is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SEC61B: Necessary for protein translocation in the endoplasmic reticulum. Belongs to the SEC61-beta family. |
| UniProt Protein Details: | Protein type:Endoplasmic reticulum; Membrane protein, integral Chromosomal Location of Human Ortholog: 9q22.33 Cellular Component: membrane; endoplasmic reticulum; integral to membrane Molecular Function:protein binding; epidermal growth factor binding Biological Process: retrograde protein transport, ER to cytosol; SRP-dependent cotranslational protein targeting to membrane; antigen processing and presentation of peptide antigen via MHC class I; ER-associated protein catabolic process; cellular protein metabolic process; translation; protein import into nucleus, translocation; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression |
| NCBI Summary: | The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P60468 |
| NCBI GenInfo Identifier: | 42560366 |
| NCBI Gene ID: | 10952 |
| NCBI Accession: | P60468.2 |
| UniProt Related Accession: | P60468 |
| Molecular Weight: | |
| NCBI Full Name: | Protein transport protein Sec61 subunit beta |
| NCBI Synonym Full Names: | SEC61 translocon beta subunit |
| NCBI Official Symbol: | SEC61B |
| NCBI Protein Information: | protein transport protein Sec61 subunit beta |
| UniProt Protein Name: | Protein transport protein Sec61 subunit beta |
| UniProt Gene Name: | SEC61B |
| UniProt Entry Name: | SC61B_HUMAN |
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