Description
| Product Name: | Human S100A5 Recombinant Protein |
| Product Code: | RPPB4558 |
| Size: | 20µg |
| Species: | Human |
| Target: | S100A5 |
| Synonyms: | Protein S100-A5, Protein S-100D, S100 calcium-binding protein A5, S100A5, S100D. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The S100A5 solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 30% glycerol, 0.1M NaCl and 0.1mM PMSF. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH METPLEKALT TMVTTFHKYS GREGSKLTLS RKELKELIKK ELCLGEMKES SIDDLMKSLD KNSDQEIDFK EYSVFLTMLC MAYNDFFLED NK |
S100 calcium binding protein A5 (S100A5) belongs to the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 family members are localized in the cytoplasm and/or nucleus of a wide range of cells, and are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100A5 has a Ca2+ affinity 20-100 fold higher than the other S100 proteins investigated under identical conditions. Furthermore, S100A5 protein binds Zn2+ and Cu2+, and Cu2+ strongly which harms the binding of Ca2+. S100A5 is expressed in very limited regions of the adult brain.
S100A5 Human Recombinant fused with a�20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing�112 amino acids (1-92 a.a.) and having a molecular mass of 12.9kDa. The S100A5 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | S100A5: Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites. Belongs to the S-100 family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 1q21 Cellular Component: cell soma; nucleus Molecular Function:protein homodimerization activity; copper ion binding; zinc ion binding; calcium ion binding |
| NCBI Summary: | The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has a Ca2+ affinity 20- to 100-fold higher than the other S100 proteins studied under identical conditions. This protein also binds Zn2+ and Cu2+, and Cu2+ strongly which impairs the binding of Ca2+. This protein is expressed in very restricted regions of the adult brain. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P33763 |
| NCBI GenInfo Identifier: | 62739837 |
| NCBI Gene ID: | 6276 |
| NCBI Accession: | AAH93957.1 |
| UniProt Secondary Accession: | P33763,Q5RHS3, |
| UniProt Related Accession: | P33763 |
| Molecular Weight: | 10,744 Da |
| NCBI Full Name: | S100 calcium binding protein A5 |
| NCBI Synonym Full Names: | S100 calcium binding protein A5 |
| NCBI Official Symbol: | S100A5�� |
| NCBI Official Synonym Symbols: | S100D�� |
| NCBI Protein Information: | protein S100-A5; S100 calcium-binding protein A5 |
| UniProt Protein Name: | Protein S100-A5 |
| UniProt Synonym Protein Names: | Protein S-100D; S100 calcium-binding protein A5 |
| Protein Family: | Protein |
| UniProt Gene Name: | S100A5�� |
| UniProt Entry Name: | S10A5_HUMAN |
