Human PON2 Recombinant Protein (RPPB2145)
- SKU:
- RPPB2145
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- PON2
- Synonyms:
- Serum paraoxonase
- arylesterase 2
- EC 3112
- EC 3181
- Source:
- Escherichia Coli
- Uniprot:
- Q15165
Description
| Product Name: | Human PON2 Recombinant Protein |
| Product Code: | RPPB2145 |
| Size: | 10µg |
| Species: | Human |
| Target: | PON2 |
| Synonyms: | Serum paraoxonase, arylesterase 2, EC 3.1.1.2, EC 3.1.8.1, PON 2, Serum aryldialkylphosphatase 2, A-esterase 2, Aromatic esterase 2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | PON2 is supplied in PBS and 50% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 1-2 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. Single band on Western Blot. |
| Amino Acid Sequence: | MGRLVAVGLLGIALALLGERLLALRNRLKASREVESVDLPHCHLIKGIEAGSEDIDILPNGLAFFSVGLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRISRGFDLASFNPHGISTFIDNDDTVYLFVVNHPEFKNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYATNDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADILAHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVYDPNNPPSSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRALYCELZ |
Paraoxonase 2 (PON2) is a member of a multigene family whose genes share 65% identity at the amino acid level, and is expressed in a variety of tissues, including the pancreas. PON2 overexpression has been shown to lower the intracellular oxidative state and reduce the cells ability to oxidize LDL. PON2 is therefore implicated in the modulation of oxidative stress.
Paraoxonase-2 Human Recombinant is expressed in E. coli having a molecular weight of 43.5 kDa and fused to an amino terminal hexahistidine tag.The PON2 purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PON2: Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis. Belongs to the paraoxonase family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.1.1.81; Hydrolase; EC 3.1.1.2; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 7q21.3 Cellular Component: mitochondrion; lysosome; plasma membrane; extracellular region; nucleus Molecular Function:identical protein binding; arylesterase activity; metal ion binding Biological Process: response to oxidative stress; aromatic compound catabolic process |
| UniProt Code: | Q15165 |
| NCBI GenInfo Identifier: | 325511384 |
| NCBI Gene ID: | |
| NCBI Accession: | Q15165.3 |
| Molecular Weight: | |
| NCBI Full Name: | Serum paraoxonase/arylesterase 2 |
| UniProt Protein Name: | Serum paraoxonase/arylesterase 2 |
| UniProt Synonym Protein Names: | Aromatic esterase 2; A-esterase 2; Serum aryldialkylphosphatase 2 |
| Protein Family: | Serum paraoxonase/arylesterase |
| UniProt Gene Name: | PON2 |
| UniProt Entry Name: | PON2_HUMAN |
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