Human PLSCR3 Recombinant Protein (RPPB4262)
- SKU:
- RPPB4262
- Product type:
- Recombinant Protein
- Size:
- 25ug
- Species:
- Human
- Target:
- PLSCR3
- Synonyms:
- Phospholipid scramblase 3
- PL scramblase 3
- Ca(2+)-dependentphospholipid scramblase 3
- Source:
- Escherichia Coli
- Uniprot:
- Q9NRY6
Description
| Product Name: | Human PLSCR3 Recombinant Protein |
| Product Code: | RPPB4262 |
| Size: | 25µg |
| Species: | Human |
| Target: | PLSCR3 |
| Synonyms: | Phospholipid scramblase 3, PL scramblase 3, Ca(2+)-dependentphospholipid scramblase 3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | PLSCR3 protein solution (1mg/ml) containing 20mM Tris-HClbuffer (pH 8.0), 10% glycerol and 0.4M urea. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAGYLPP KGYAPSPPPP YPVTPGYPEP ALHPGPGQAP VPAQVPAPAPGFALFPSPGP VALGSAAPFL PLPGVPSGLE FLVQIDQILI HQKAERVETF LGWETCNRYE LRSGAGQPLGQAAEESNCCA RLCCGARRPL RVRLADPGDR EVLRLLRPLH CGCSCCPCGL QEMEVQAPPG TTIGHVLQTW HPFLPKFSIQ DADRQTVLRVVGPCWTCGCG TDTNFEVKTR DESRSVGRIS KQWGGLVREA LTDADDFGLQ FPLDLDVR |
PhospholipidScramblase 3, (PLSCR3) may mediate accelerated ATP-independent bidirectionaltransbilayer migration of phospholipids upon binding calcium ions which resultsin a loss of phospholipid asymmetry in the plasma membrane. PLSCR3may play a key role in the initiation of fibrin clot formation, in theactivation of mast cells and in the recognition of apoptotic and injured cellsby the reticuloendothelial system. In addition, PLSCR3 seems to play a role inapoptosis, throughtranslocation of cardiolipin from the inner to the outer mitochondrial membranewhich promotes BID recruitment and enhances tBid-induced mitochondrial damages.Among the diseases associated with PLSCR3 are brain ischemia, and ischemia.
PLSCR3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 288 amino acids (1-265 a.a) and having a molecular mass of 30.9kDa.PLSCR3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PLSCR3: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Belongs to the phospholipid scramblase family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 17p13.1 Cellular Component: mitochondrion; plasma membrane Molecular Function:calcium-dependent protein binding; phospholipid scramblase activity; protein binding |
| UniProt Code: | Q9NRY6 |
| NCBI GenInfo Identifier: | 296452876 |
| NCBI Gene ID: | 57048 |
| NCBI Accession: | Q9NRY6.2 |
| UniProt Secondary Accession: | Q9NRY6,Q567U0, Q8NBW6, Q96F13, A8K252, |
| UniProt Related Accession: | Q9NRY6 |
| Molecular Weight: | 32kDa |
| NCBI Full Name: | Phospholipid scramblase 3 |
| NCBI Synonym Full Names: | phospholipid scramblase 3 |
| NCBI Official Symbol: | PLSCR3 |
| NCBI Protein Information: | phospholipid scramblase 3 |
| UniProt Protein Name: | Phospholipid scramblase 3 |
| UniProt Synonym Protein Names: | Ca(2+)-dependent phospholipid scramblase 3 |
| Protein Family: | Phospholipid scramblase |
| UniProt Gene Name: | PLSCR3 |
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