Human PGLS Recombinant Protein (RPPB2101)
- SKU:
- RPPB2101
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- PGLS
- Synonyms:
- 6PGL
- 6-Phosphogluconolactonase
- Source:
- Escherichia Coli
- Uniprot:
- O95336
Description
| Product Name: | Human PGLS Recombinant Protein |
| Product Code: | RPPB2101 |
| Size: | 10µg |
| Species: | Human |
| Target: | PGLS |
| Synonyms: | 6PGL, 6-Phosphogluconolactonase. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The PGLS protein solution (1mg/1ml) is formulated in 20mM Tris-HCl buffer (pH 8.0) 1mM DTT, 100mM NaCl and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.Please avoid freeze thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MAAPAPGLIS VFSSSQELGA ALAQLVAQRA ACCLAGARAR FALGLSGGSL VSMLARELPA AVAPAGPASL ARWTLGFCDE RLVPFDHAES TYGLYRTHLL SRLPIPESQV ITINPELPVE EAAEDYAKKL RQAFQGDSIP VFDLLILGVG PDGHTCSLFP DHPLLQEREK IVAPISDSPK PPPQRVTLTL PVLNAARTVI FVATGEGKAA VLKRILEDQE ENPLPAALVQ PHTGKLCWFL DEAAARLLTV PFEKHSTL |
PGLS is an enzyme in the second step pentose phosphate pathway. 6-Phosphogluconolactonase is crucial for the synthesis of nucleotide sugars and NADPH, the key cause for decreasing power. PGLS transforms 6-phosphogluconolactone to 6-phosphogluconate.
PGLS produced in E.Coli is a single, non-glycosylated polypeptide chain containing 278 amino acids (1-258a.a.) and having a molecular mass of 29.7kDa.PGLS is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PGLS: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate. Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily. |
| UniProt Protein Details: | Protein type:EC 3.1.1.31; Hydrolase; Carbohydrate Metabolism - pentose phosphate pathway Chromosomal Location of Human Ortholog: 19p13.2 Cellular Component: cytosol Molecular Function:6-phosphogluconolactonase activity; protein binding Biological Process: pentose-phosphate shunt |
| UniProt Code: | O95336 |
| NCBI GenInfo Identifier: | 7387511 |
| NCBI Gene ID: | 25796 |
| NCBI Accession: | O95336.2 |
| UniProt Related Accession: | O95336 |
| Molecular Weight: | 27,547 Da |
| NCBI Full Name: | 6-phosphogluconolactonase |
| NCBI Synonym Full Names: | 6-phosphogluconolactonase |
| NCBI Official Symbol: | PGLS |
| NCBI Official Synonym Symbols: | 6PGL; HEL-S-304 |
| NCBI Protein Information: | 6-phosphogluconolactonase |
| UniProt Protein Name: | 6-phosphogluconolactonase |
| UniProt Gene Name: | PGLS |
| UniProt Entry Name: | 6PGL_HUMAN |
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