Human PDCL Recombinant Protein (RPPB4213)
- SKU:
- RPPB4213
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- PDCL
- Synonyms:
- Phosducin-like protein
- PHLP
- DKFZp564M1863
- Source:
- Escherichia Coli
- Uniprot:
- Q13371
Description
| Product Name: | Human PDCL Recombinant Protein |
| Product Code: | RPPB4213 |
| Size: | 10µg |
| Species: | Human |
| Target: | PDCL |
| Synonyms: | Phosducin-like protein, PHLP, DKFZp564M1863. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The PDCL solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 100mM NaCl, 1mM DTT and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMTTLDD KLLGEKLQYY YSSSEDEDSD HEDKDRGRCA PASSSVPAEA ELAGEGISVN TGPKGVINDW RRFKQLETEQ REEQCREMER LIKKLSMTCR SHLDEEEEQQ KQKDLQEKIS GKMTLKEFAI MNEDQDDEEF LQQYRKQRME EMRQQLHKGP QFKQVFEISS GEGFLDMIDK EQKSIVIMVH IYEDGIPGTE AMNGCMICLA AEYPAVKFCK VKSSVIGASS QFTRNALPAL LIYKGGELIG NFVRVTDQLG DDFFAVDLEA FLQEFGLLPE KEVLVLTSVR NSATCHSEDS DLEID |
Phosducin-like protein (PDCL) is a member of the phosducin family. PDCL is a putative modulator of heterotrimeric G proteins. PDCL shares broad amino acid sequence homology with phosducin, a phosphoprotein expressed in the retina and pineal gland. Both PDCL and phosphoducin regulate G-protein signaling by binding to the beta-gamma subunits of G proteins.
PDCL Human Recombinant produced in E. coli is a single polypeptide chain containing 325 amino acids (1-301) and having a molecular mass of 36.8 kDa.PDCL is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PhLP: a member of the phosducin family of G-protein beta-gamma regulators. Shares extensive amino acid sequence homology with phosducin, a phosphoprotein expressed in retina and pineal gland. Both phosducin-like protein and phosphoducin have been shown to regulate G-protein signaling by binding to the beta-gamma subunits of G proteins. Two splice variants have been described. |
| UniProt Protein Details: | Protein type:G protein regulator, misc. Chromosomal Location of Human Ortholog: 9q12-q13 Cellular Component: cytoplasm Molecular Function:protein binding; receptor signaling protein activity; protein complex binding Biological Process: protein folding; visual perception; signal transduction; regulation of G-protein coupled receptor protein signaling pathway |
| NCBI Summary: | Phosducin-like protein is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin, a phosphoprotein expressed in retina and pineal gland. Both phosducin-like protein and phosphoducin have been shown to regulate G-protein signaling by binding to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13371 |
| NCBI GenInfo Identifier: | 27808673 |
| NCBI Gene ID: | 5082 |
| NCBI Accession: | Q13371.3 |
| UniProt Secondary Accession: | Q13371,Q63737, Q9DBX2, Q2HJA9, |
| UniProt Related Accession: | Q13371 |
| Molecular Weight: | 34282 |
| NCBI Full Name: | Phosducin-like protein |
| NCBI Synonym Full Names: | phosducin like |
| NCBI Official Symbol: | PDCL |
| NCBI Official Synonym Symbols: | PhLP |
| NCBI Protein Information: | phosducin-like protein |
| UniProt Protein Name: | Phosducin-like protein |
| Protein Family: | Phosducin-like protein |
| UniProt Gene Name: | PDCL |
| UniProt Entry Name: | PHLP_HUMAN |
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