Human PARD6B Recombinant Protein (RPPB4185)
- SKU:
- RPPB4185
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- PARD6B
- Synonyms:
- Partitioning defective 6 homolog beta
- PAR-6 beta
- PAR-6B
- PARD6B
- Source:
- Escherichia Coli
- Uniprot:
- Q9BYG5
Description
| Product Name: | Human PARD6B Recombinant Protein |
| Product Code: | RPPB4185 |
| Size: | 10µg |
| Species: | Human |
| Target: | PARD6B |
| Synonyms: | Partitioning defective 6 homolog beta, PAR-6 beta, PAR-6B, PARD6B, PAR6B. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The PARD6B solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 2M Urea, 20% glycerol and 0.2M NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMNRSHRH GAGSGCLGTM EVKSKFGAEF RRFSLERSKP GKFEEFYGLL QHVHKIPNVD VLVGYADIHG DLLPINNDDN YHKAVSTANP LLRIFIQKKE EADYSAFGTD TLIKKKNVLT NVLRPDNHRK KPHIVISMPQ DFRPVSSIID VDILPETHRR VRLYKYGTEK PLGFYIRDGS SVRVTPHGLE KVPGIFISRL VPGGLAQSTG LLAVNDEVLE VNGIEVSGKS LDQVTDMMIA NSRNLIITVR PANQRNNVVR NSRTSGSSGQ STDNSLLGYP QQIEPSFEPE DEDSEEDDII IEDNGVPQQI PKAVPNTESL ESLTQIELSF ESGQNGFIPS NEVSLAAIAS SSNTEFETHA PDQKLLEEDG TIITL |
Partitioning defective 6 homolog beta (PARD6B) belongs to the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. Cellular asymmetry is crucial for the development of multicellular organisms. PARD (partitioning-defective) proteins have central roles in asymmetric cell division and polarized growth, whereas Cdc42 and Rac mediate establishment of cell growth and polarity and contribute to oncogenic transformation by Ras. PARD6B is expressed in pancreas and in both the adult and the fetal kidney, and is weakly expressed in the placenta and the lung.
PARD6B Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 395 amino acids (1-372) and having a molecular mass of 43.6kDa.PARD6B is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PARD6B: Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Belongs to the PAR6 family. |
| UniProt Protein Details: | Protein type:Cell adhesion Chromosomal Location of Human Ortholog: 20q13.13 Cellular Component: protein complex; tight junction; apical part of cell; cytoplasm; plasma membrane; cell cortex; nucleus; cytosol Molecular Function:protein binding Biological Process: intercellular junction assembly; intercellular junction assembly and maintenance; axonogenesis; cell division; establishment and/or maintenance of cell polarity; protein complex assembly; cell cycle; regulation of cell migration |
| NCBI Summary: | This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9BYG5 |
| NCBI GenInfo Identifier: | 30913176 |
| NCBI Gene ID: | 84612 |
| NCBI Accession: | Q9BYG5.1 |
| UniProt Secondary Accession: | Q9BYG5,Q9Y510, A2A2A7, |
| UniProt Related Accession: | Q9BYG5 |
| Molecular Weight: | 372 |
| NCBI Full Name: | Partitioning defective 6 homolog beta |
| NCBI Synonym Full Names: | par-6 family cell polarity regulator beta |
| NCBI Official Symbol: | PARD6B |
| NCBI Official Synonym Symbols: | PAR6B |
| NCBI Protein Information: | partitioning defective 6 homolog beta; PAR-6 beta; par-6 partitioning defective 6 homolog beta |
| UniProt Protein Name: | Partitioning defective 6 homolog beta |
| Protein Family: | Partitioning defective |
| UniProt Gene Name: | PARD6B |
| UniProt Entry Name: | PAR6B_HUMAN |
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