Human OMG Recombinant Protein (RPPB4157)
- SKU:
- RPPB4157
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P23515
Description
| Product Name: | Human OMG Recombinant Protein |
| Product Code: | RPPB4157 |
| Size: | 10µg |
| Species: | Human |
| Target: | OMG |
| Synonyms: | Oligodendrocyte-myelin glycoprotein, OMG, OMGP. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | OMG protein solution (0.5mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by analysis by SDS-PAGE. |
| Amino Acid Sequence: | ICPLQCICTE RHRHVDCSGR NLSTLPSGLQ ENIIHLNLSY NHFTDLHNQL TQYTNLRTLD ISNNRLESLP AHLPRSLWNM SAANNNIKLL DKSDTAYQWN LKYLDVSKNM LEKVVLIKNT LRSLEVLNLS SNKLWTVPTN MPSKLHIVDL SNNSLTQILP GTLINLTNLT HLYLHNNKFT FIPDQSFDQL FQLQEITLYN NRWSCDHKQN ITYLLKWMME TKAHVIGTPC STQISSLKEH NMYPTPSGFT SSLFTVSGMQ TVDTINSLSV VTQPKVTKIP KQYRTKETTF GATLSKDTTF TSTDKAFVPY PEDTSTETIN SHEAAAATLT IHLQDGMVTN TSLTSSTKSS PTPMTLSITS GMPNNFSEMP QQSTTLNLWR EETTTNVKTP LPSVEHHHHH H |
Oligodendrocyte-myelin glycoprotein (OMG) is a cell membrane protein which contains 8 leucine-rich repeats. The OMG protein is expressed on the surface of oligodendrocytes and on large projection neurons, including Purkinje cells of the cerebellum, pyramidal cells of the hippocampus, motoneurons of the brainstem and anterior horn cells of the spinal cord. The neurite outgrowth inhibitory activities of all three myelin-derived proteins are mediated by binding to a joint receptor complex consisting of the Nogo receptor and the p75 neurotrophin receptor.
OMG Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 401 amino acids (25-418) and having a molecular mass of 45.4kDa (Molecular size on SDS-PAGE will appear at approximately 50-100kDa).OMG is fused to 8 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | OMG: Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system. |
| UniProt Protein Details: | Protein type:Membrane protein, GPI anchor Chromosomal Location of Human Ortholog: 17q11.2 Cellular Component: plasma membrane Molecular Function:identical protein binding Biological Process: axonogenesis; cell adhesion; negative regulation of axonogenesis; nerve growth factor receptor signaling pathway; neurite regeneration; regulation of axonogenesis; regulation of collateral sprouting of intact axon in response to injury |
| UniProt Code: | P23515 |
| NCBI GenInfo Identifier: | 129122 |
| NCBI Gene ID: | 4974 |
| NCBI Accession: | P23515.2 |
| UniProt Secondary Accession: | P23515,E1P659, |
| UniProt Related Accession: | P23515 |
| Molecular Weight: | 49,608 Da |
| NCBI Full Name: | Oligodendrocyte-myelin glycoprotein |
| NCBI Synonym Full Names: | oligodendrocyte myelin glycoprotein |
| NCBI Official Symbol: | OMG�� |
| NCBI Official Synonym Symbols: | OMGP�� |
| NCBI Protein Information: | oligodendrocyte-myelin glycoprotein |
| UniProt Protein Name: | Oligodendrocyte-myelin glycoprotein |
| Protein Family: | Oligodendrocyte-myelin glycoprotein |
| UniProt Gene Name: | OMG�� |
| UniProt Entry Name: | OMGP_HUMAN |