Human NDUFA2 Recombinant Protein (RPPB2003)
- SKU:
- RPPB2003
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- NDUFA2
- Synonyms:
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
- Complex I-B8
- CI-B8
- NADH-ubiquinone oxidoreductase B8 subunit
- Source:
- Escherichia Coli
- Uniprot:
- O43678
Description
| Product Name: | Human NDUFA2 Recombinant Protein |
| Product Code: | RPPB2003 |
| Size: | 10µg |
| Species: | Human |
| Target: | NDUFA2 |
| Synonyms: | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2, Complex I-B8, CI-B8, NADH-ubiquinone oxidoreductase B8 subunit, NDUFA2, CD14, CIB8. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The NDUFA2 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAAAAAS RGVGAKLGLR EIRIHLCQRS PGSQGVRDFI EKRYVELKKA NPDLPILIRE CSDVQPKLWA RYAFGQETNV PLNNFSADQV TRALENVLSG KA |
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (NDUFA5) is a member of the complex I NDUFA5 subunit family. The human NDUFA5 gene codes for the B13 subunit of complex I of the respiratory chain that transfers electrons from NADH to ubiquinone. The NDUFA5 protein localizes to the inner mitochondrial membrane as part of the seven component-containing, water soluble 'iron-sulfur protein' (IP) fraction of complex I, even though its exact role is undetermined.
NDUFA2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 122 amino acids (1-99) and having a molecular mass of 13.3kDa.NDUFA2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | NDUFA2: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. |
| UniProt Protein Details: | Protein type:Mitochondrial; EC 1.6.99.3; Oxidoreductase; EC 1.6.5.3; Energy Metabolism - oxidative phosphorylation Chromosomal Location of Human Ortholog: 5q31.2 Cellular Component: mitochondrial inner membrane; mitochondrial membrane; mitochondrial respiratory chain complex I Molecular Function:NADH dehydrogenase (ubiquinone) activity Biological Process: cellular metabolic process; mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I assembly Disease: Leigh Syndrome |
| NCBI Summary: | The encoded protein is a subunit of the hydrophobic protein fraction of the NADH:ubiquinone oxidoreductase (complex 1), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane, and may be involved in regulating complex I activity or its assembly via assistance in redox processes. Mutations in this gene are associated with Leigh syndrome, an early-onset progressive neurodegenerative disorder. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010] |
| UniProt Code: | O43678 |
| NCBI GenInfo Identifier: | 297206774 |
| NCBI Gene ID: | 4695 |
| NCBI Accession: | NP_001171941.1 |
| UniProt Secondary Accession: | O43678,Q6IAY8, D6RJD6, |
| UniProt Related Accession: | O43678 |
| Molecular Weight: | 8,491 Da |
| NCBI Full Name: | NADH dehydrogenase |
| NCBI Synonym Full Names: | NADH:ubiquinone oxidoreductase subunit A2 |
| NCBI Official Symbol: | NDUFA2 |
| NCBI Official Synonym Symbols: | B8; CD14; CIB8 |
| NCBI Protein Information: | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 |
| UniProt Protein Name: | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 |
| UniProt Synonym Protein Names: | Complex I-B8; CI-B8; NADH-ubiquinone oxidoreductase B8 subunit |
| Protein Family: | NADH dehydrogenase |
| UniProt Gene Name: | NDUFA2 |
| UniProt Entry Name: | NDUA2_HUMAN |
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