Human MSRB2 Recombinant Protein (RPPB1981)
- SKU:
- RPPB1981
- Product type:
- Recombinant Protein
- Size:
- 25ug
- Species:
- Human
- Target:
- MSRB2
- Synonyms:
- CBS-1
- PILB
- Pilin-like Transcription Factor
- MSRB
- Source:
- Escherichia Coli
- Uniprot:
- Q9Y3D2
Description
| Product Name: | Human MSRB2 Recombinant Protein |
| Product Code: | RPPB1981 |
| Size: | 25µg |
| Species: | Human |
| Target: | MSRB2 |
| Synonyms: | CBS-1, PILB, Pilin-like Transcription Factor, MSRB, CGI-131, Mmethionine Sulfoxide Reductase B2, Methionine-R-Sulfoxide Reductase B2 Mitochondrial, MGC26104, MsrB2. EC 1.8.4. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The MSRB2 protein solution (1mg/1ml) is formulated in In 20 mM Tris-HCl Buffer (pH 7.5), 1 mM DTT, 0.1 mM PMSF and 10% Glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.Please avoid freeze thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MVRGQAGGGG PGTGPGLGEA GSLATCELPL AKSEWQKKLT PEQFYVTREK GTEPPFSGIY LNNKEAGMYH CVCCDSPLFS SEKKYCSGTG WPSFSEAHGT SGSDESHTGI LRRLDTSLGS ARTEVVCKQC EAHLGHVFPD GPGPNGQRFC INSVALKFKP RKH |
MSRB2 is a member of the methionine sulfoxide reductases(MSRs) family which are antioxidant repair enzymes. MSRB2 protein catalyzes the decrease of free and protein-bound methionine sulfoxide to methionine. MSRB2 has a part in protecting against oxidative stress in numerous organs.
MSRB2 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 183 amino acids (21-182a.a.) and having a molecular mass of 19.5kDa.MSRB2 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | MSRB2: Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance. Belongs to the MsrB Met sulfoxide reductase family. |
| UniProt Protein Details: | Protein type:EC 1.8.4.-; Oxidoreductase; Mitochondrial; Transcription factor Chromosomal Location of Human Ortholog: 10p12 Cellular Component: mitochondrion Molecular Function:zinc ion binding; peptide-methionine (R)-S-oxide reductase activity; actin binding; transcription factor activity Biological Process: protein repair; regulation of transcription, DNA-dependent; actin filament polymerization; response to oxidative stress |
| UniProt Code: | Q9Y3D2 |
| NCBI GenInfo Identifier: | 182676405 |
| NCBI Gene ID: | 22921 |
| NCBI Accession: | Q9Y3D2.2 |
| UniProt Secondary Accession: | Q9Y3D2,Q17R44, Q4G1C7, Q9Y5W6, |
| UniProt Related Accession: | Q9Y3D2 |
| Molecular Weight: | 19,536 Da |
| NCBI Full Name: | Methionine-R-sulfoxide reductase B2, mitochondrial |
| NCBI Synonym Full Names: | methionine sulfoxide reductase B2 |
| NCBI Official Symbol: | MSRB2 |
| NCBI Official Synonym Symbols: | CBS1; MSRB; PILB; CBS-1; CGI-131 |
| NCBI Protein Information: | methionine-R-sulfoxide reductase B2, mitochondrial; pilin-like transcription factor |
| UniProt Protein Name: | Methionine-R-sulfoxide reductase B2, mitochondrial |
| Protein Family: | Methionine-R-sulfoxide reductase |
| UniProt Gene Name: | MSRB2 |
| UniProt Entry Name: | MSRB2_HUMAN |
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