Human MAPRE3 Recombinant Protein (RPPB3927)
- SKU:
- RPPB3927
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- MAPRE3
- Synonyms:
- RP3
- EB3
- EBF3
- End-binding protein 3
- Source:
- Escherichia Coli
- Uniprot:
- Q9UPY8
Description
| Product Name: | Human MAPRE3 Recombinant Protein |
| Product Code: | RPPB3927 |
| Size: | 20µg |
| Species: | Human |
| Target: | MAPRE3 |
| Synonyms: | RP3, EB3, EBF3, End-binding protein 3, EBF3-S, APC binding protein. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The MAPRE3 protein solution (1mg/1ml) is formulated in 20mM Tris-HCl buffer (pH 8.0) 2mM DTT, 0.1M NaCl and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.Please avoid freeze thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MAVNVYSTSV TSENLSRHDM LAWVNDSLHL NYTKIEQLCS GAAYCQFMDM LFPGCVHLRK VKFQAKLEHE YIHNFKVLQA AFKKMGVDKI IPVEKLVKGK FQDNFEFIQW FKKFFDANYD GKDYNPLLAR QGQDVAPPPN PGDQIFNKSK KLIGTAVPQR TSPTGPKNMQ TSGRLSNVAP PCILRKNPPS ARNGGHETDA QILELNQQLV DLKLTVDGLE KERDFYFSKL RDIELICQEH ESENSPVISG IIGILYATEE GFAPPEDDEI EEHQQEDQDE Y |
MAPRE3 is a microtubule related protein that cooperates with the colorectal adenomatous polyposis coli tumor suppressor protein and takes a curtail part in regulating microtubule dynamics, cell polarity, and chromosome stability. MAPRE3 protein is related to MAPRE1 and also associates with the microtubule cytoskeleton. MAPRE3 is expressed mainly in the central nervous system and specially associates with APCL, a homolog of the adenomatous polyposis coli tumor suppressor protein.
MAPRE3 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 301 amino acids (1-281a.a.) and having a molecular mass of 34.1kDa.MAPRE3 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | EB3: Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration. Belongs to the MAPRE family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Microtubule-binding Chromosomal Location of Human Ortholog: 2p23.3-p23.1 Cellular Component: microtubule cytoskeleton; cytoplasmic microtubule; perinuclear region of cytoplasm; cytoplasm; midbody Molecular Function:protein binding; microtubule binding Biological Process: mitosis; positive regulation of cyclin-dependent protein kinase activity; cell division; positive regulation of transcription, DNA-dependent |
| UniProt Code: | Q9UPY8 |
| NCBI GenInfo Identifier: | 10800412 |
| NCBI Gene ID: | |
| NCBI Accession: | NP_036458.2 |
| Molecular Weight: | ~ 32kDa |
| NCBI Full Name: | microtubule-associated protein RP/EB family member 3 |
| UniProt Protein Name: | Microtubule-associated protein RP/EB family member 3 |
| UniProt Synonym Protein Names: | EB1 protein family member 3; EBF3; End-binding protein 3; EB3; RP3 |
| UniProt Gene Name: | MAPRE3 |
| UniProt Entry Name: | MARE3_HUMAN |
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