Human LOX Recombinant Protein (RPPB1909)
- SKU:
- RPPB1909
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- LOX
- Synonyms:
- Lysyl Oxidase
- EC 14313
- Protein-lysine 6-oxidase
- Lysyloxidase
- Source:
- Escherichia Coli
- Uniprot:
- P28300
Description
| Product Name: | Human LOX Recombinant Protein |
| Product Code: | RPPB1909 |
| Size: | 20µg |
| Species: | Human |
| Target: | LOX |
| Synonyms: | Lysyl Oxidase, EC 1.4.3.13, Protein-lysine 6-oxidase, Lysyloxidase. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | LOX protein solution (1mg/ml) containing 20mM Tris-HClbuffer (pH 8.0) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSDDPYNPY KYSDDNPYYN YYDTYERPRP GGRYRPGYGT GYFQYGLPDLVADPYYIQAS TYVQKMSMYN LRCAAEENCL ASTAYRADVR DYDHRVLLRF PQRVKNQGTS DFLPSRPRYSWEWHSCHQHY HSMDEFSHYD LLDANTQRRV AEGHKASFCLEDTSCDYGYH RRFACTAHTQ GLSPGCYDTY GADIDCQWID ITDVKPGNYILKVSVNPSYL VPESDYTNNV VRCDIRYTGH HAYASGCTIS PY |
Lysyl Oxidase also known as LOX is an extracellular copper enzyme which initiates the crosslinking ofcollagens and elastin. LOX catalyzesoxidative deamination of the epsilon-amino group in certain lysine andhydroxylysine residues of collagens and lysine residues of elastin. Adding upto crosslinking extracellular matrix proteins, LOX plays a part in tumorsuppression. Moreover, defects in LOX are the cause of autosomal recessivecutis laxa type I, CL type I. Two transcript variants encoding dissimilar isoformshave been found for LOX.
LOX Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 272 amino acids (169-417a.a) andhaving a molecular mass of 31.4kDa.LOX is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | LOX: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression. Belongs to the lysyl oxidase family. |
| UniProt Protein Details: | Protein type:EC 1.4.3.13; Secreted; Secreted, signal peptide; Oxidoreductase Chromosomal Location of Human Ortholog: 5q23.2 Cellular Component: extracellular region Molecular Function:protein binding Biological Process: extracellular matrix organization and biogenesis; protein modification process Disease: Cutis Laxa, Autosomal Recessive, Type Ia |
| NCBI Summary: | This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. [provided by RefSeq, Jul 2016] |
| UniProt Code: | P28300 |
| NCBI GenInfo Identifier: | 417269 |
| NCBI Gene ID: | 4015 |
| NCBI Accession: | P28300.2 |
| UniProt Secondary Accession: | P28300,Q5FWF0, B2R5Q3, |
| UniProt Related Accession: | P28300 |
| Molecular Weight: | 46,944 Da |
| NCBI Full Name: | Protein-lysine 6-oxidase |
| NCBI Synonym Full Names: | lysyl oxidase |
| NCBI Official Symbol: | LOX |
| NCBI Protein Information: | protein-lysine 6-oxidase |
| UniProt Protein Name: | Protein-lysine 6-oxidase |
| UniProt Synonym Protein Names: | Lysyl oxidase |
| Protein Family: | Linoleate 9/13-lipoxygenase |
| UniProt Gene Name: | LOX |
| UniProt Entry Name: | LYOX_HUMAN |
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