Human KRT18 Recombinant Protein (RPPB3817)
- SKU:
- RPPB3817
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- KRT18
- Synonyms:
- Keratin type I cytoskeletal 18
- Cytokeratin-18
- CK-18
- Keratin-18
- Source:
- Escherichia Coli
- Uniprot:
- P05783
Description
| Product Name: | Human KRT18 Recombinant Protein |
| Product Code: | RPPB3817 |
| Size: | 20µg |
| Species: | Human |
| Target: | KRT18 |
| Synonyms: | Keratin type I cytoskeletal 18, Cytokeratin-18, CK-18, Keratin-18, K18, KRT18,CYK18,Cell proliferation-inducing gene 46 protein. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The protein (1mg/ml) was lyophilized from a sterile solution containing 30mM Tris-HCl pH-8, 9.5M urea, 2mM EDTA, 2mM DTT and 10mM methylammonium chloride. |
| Solubility: | It is recommended to reconstitute the lyophilized 1mg CK-18 in sterile 18M?-cm H2O not less than 700µl, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized CK-18 although stable at room temperature for 3 weeks, should be stored between 2-8°C. Upon reconstitution CK-18 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by analysis by SDS-PAGE. |
KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.
Cytokeratin 18 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain having a calculated molecular mass of 48,201 Dalton, showing a 45kDa band on SDS-page, pI-5.7.The KRT18 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | K18: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Keratin 18 and its filament partner keratin 8 are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Defects are a cause of cryptogenic cirrhosis. |
| UniProt Protein Details: | Protein type:Nucleolus; Cytoskeletal Chromosomal Location of Human Ortholog: 12q13 Cellular Component: cytoplasm; intermediate filament; keratin filament; microtubule organizing center; nucleolus; perinuclear region of cytoplasm Molecular Function:protein binding; structural molecule activity Biological Process: anatomical structure morphogenesis; cell cycle; Golgi to plasma membrane CFTR protein transport; intermediate filament cytoskeleton organization and biogenesis; negative regulation of apoptosis; tumor necrosis factor-mediated signaling pathway; viral reproduction Disease: Cirrhosis, Familial |
| NCBI Summary: | KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P05783 |
| NCBI GenInfo Identifier: | 125083 |
| NCBI Gene ID: | 3875 |
| NCBI Accession: | P05783.2 |
| UniProt Secondary Accession: | P05783,Q53G38, Q5U0N8, Q9BW26, |
| UniProt Related Accession: | P05783 |
| Molecular Weight: | |
| NCBI Full Name: | Keratin, type I cytoskeletal 18 |
| NCBI Synonym Full Names: | keratin 18 |
| NCBI Official Symbol: | KRT18 |
| NCBI Official Synonym Symbols: | K18; CK-18; CYK18 |
| NCBI Protein Information: | keratin, type I cytoskeletal 18 |
| UniProt Protein Name: | Keratin, type I cytoskeletal 18 |
| UniProt Synonym Protein Names: | Cell proliferation-inducing gene 46 protein; Cytokeratin-18; CK-18; Keratin-18; K18 |
| Protein Family: | Keratin |
| UniProt Gene Name: | KRT18 |
| UniProt Entry Name: | K1C18_HUMAN |
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