Human KLRK1 Recombinant Protein (RPPB3807)
- SKU:
- RPPB3807
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- KLRK1
- Synonyms:
- CD314
- D12S2489E
- KLR
- NKG2-D
- Source:
- Escherichia Coli
- Uniprot:
- P26718
Description
| Product Name: | Human KLRK1 Recombinant Protein |
| Product Code: | RPPB3807 |
| Size: | 20µg |
| Species: | Human |
| Target: | KLRK1 |
| Synonyms: | CD314, D12S2489E, KLR, NKG2-D, NKG2D, Killer cell lectin-like receptor subfamily K member 1, NK cell receptor D, NKG2-D-activating NK receptor, CD314. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | KLRK1 protein solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 10% glycerol and 0.4M Urea. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMIWSAVF LNSLFNQEVQ IPLTESYCGP CPKNWICYKN NCYQFFDESK NWYESQASCM SQNASLLKVY SKEDQDLLKL VKSYHWMGLV HIPTNGSWQW EDGSILSPNL LTIIEMQKGD CALYASSFKG YIENCSTPNT YICMQRTV |
Killer Cell lectin-Like Receptor Subfamily K, Member 1 (KLRK1) is an activating receptor which has recently generated considerable interest. The most fascinating of these, are a couple of closely related proteins known as MICA and MICB. These are cell-surface molecules distantly related to MHC class I proteins, and their genes have elements of heat shock promoters. Thus, MICA and MICB are expressed in the course of cell stress and are up-regulated in tumor cells and during viral infections. This receptor-ligand combination has a crucial role in the immune response to various pathologies.
KLRK1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 168 amino acids (73-216 a.a.) and having a molecular mass of 19.2kDa. KLRK1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8+ T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. |
| NCBI Summary: | This locus represents naturally occurring read-through transcription between the neighboring KLRC4 (killer cell lectin-like receptor subfamily C, member 4) and KLRK1 (killer cell lectin-like receptor subfamily K, member 1) genes on chromosome 12. The read-through transcript includes an alternate 5' exon and lacks a significant portion of the KLRC4 coding sequence, including the start codon, and it thus encodes the KLRK1 protein. [provided by RefSeq, Dec 2010] |
| UniProt Code: | P26718 |
| NCBI GenInfo Identifier: | 128370 |
| NCBI Gene ID: | 100528032 |
| NCBI Accession: | P26718.1 |
| UniProt Secondary Accession: | P26718,Q9NR41, A8K7K5, A8K7P4, |
| UniProt Related Accession: | P26718 |
| Molecular Weight: | 25,274 Da |
| NCBI Full Name: | NKG2-D type II integral membrane protein |
| NCBI Synonym Full Names: | KLRC4-KLRK1 readthrough |
| NCBI Official Symbol: | KLRC4-KLRK1 |
| NCBI Protein Information: | NKG2-D type II integral membrane protein |
| UniProt Protein Name: | NKG2-D type II integral membrane protein |
| UniProt Synonym Protein Names: | Killer cell lectin-like receptor subfamily K member 1; NK cell receptor D; NKG2-D-activating NK receptor; CD_antigen: CD314 |
| Protein Family: | NKG2-D type II integral membrane protein |
| UniProt Gene Name: | KLRK1 |
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