Human IP6K2 Recombinant Protein (RPPB2554)
- SKU:
- RPPB2554
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- IP6K2
- Synonyms:
- Inositol hexakisphosphate kinase 2 isoform a
- IHPK2
- PIUS
- InsP6 kinase 2
- Source:
- Escherichia Coli
- Uniprot:
- Q9UHH9
Description
| Product Name: | Human IP6K2 Recombinant Protein |
| Product Code: | RPPB2554 |
| Size: | 10µg |
| Species: | Human |
| Target: | IP6K2 |
| Synonyms: | Inositol hexakisphosphate kinase 2 isoform a, IHPK2, PIUS, InsP6 kinase 2, P(i)-uptake stimulator, PiUS, IP6K2, TCCCIA00113. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | IP6K2 solution (0.5mg/ml) contains Tris-HCl buffer (pH 8.0) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MSPAFRAMDV EPRAKGVLLE PFVHQVGGHS CVLRFNETTL CKPLVPREHQ FYETLPAEMR KFTPQYKGVV SVRFEEDEDR NLCLIAYPLK GDHGIVDIVD NSDCEPKSKL LRWTTNKKHH VLETEKTPKD WVRQHRKEEK MKSHKLEEEF EWLKKSEVLY YTVEKKGNIS SQLKHYNPWS MKCHQQQLQR MKENAKHRNQ YKFILLENLT SRYEVPCVLD LKMGTRQHGD DASEEKAANQ IRKCQQSTSA VIGVRVCGMQ VYQAGSGQLM FMNKYHGRKL SVQGFKEALF QFFHNGRYLR RELLGPVLKK LTELKAVLER QESYRFYSSS LLVIYDGKER PEVVLDSDAE DLEDLSEESA DESAGAYAYK PIGASSVDVR MIDFAHTTCR LYGEDTVVHE GQDAGYIFGL QSLIDIVTEI SEESGE |
Inositol Hexakisphosphate Kinase 2 (IP6K2) which is a part of the inositol IPK family converts inositol hexakisphosphate to diphosphoinositol pentakisphosphate. IP6K2 also converts 1, 3, 4, 5, 6-pentakisphosphate (InsP5) to PP-InsP4. IP6K2 is a protein coding gene which suppresses the growth and affects the apoptotic activities of IFN-beta in several ovarian cancers.
IP6K2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 446 amino acids (1-426a.a) and having a molecular mass of 51.3kDa.IP6K2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IHPK2: Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Belongs to the inositol phosphokinase (IPK) family. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Kinase, other; Motility/polarity/chemotaxis; EC 2.7.4.21 Chromosomal Location of Human Ortholog: 3p21.31 Cellular Component: intermediate filament cytoskeleton; nucleoplasm; nucleus Molecular Function:inositol 1,3,4,5,6-pentakisphosphate kinase activity; inositol heptakisphosphate kinase activity; inositol hexakisphosphate kinase activity; protein binding Biological Process: inositol phosphate metabolic process; negative regulation of cell growth; phosphoinositide phosphorylation; positive regulation of apoptosis |
| NCBI Summary: | This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UHH9 |
| NCBI GenInfo Identifier: | 50400688 |
| NCBI Gene ID: | 51447 |
| NCBI Accession: | Q9UHH9.2 |
| UniProt Secondary Accession: | Q9UHH9,Q6P0N8, Q9BSZ6, Q9BUW3, Q9H4P7, Q9NT63, Q9UFU6 A8K3B1, B4E3G6, G8JLL6, |
| UniProt Related Accession: | Q9UHH9 |
| Molecular Weight: | 9,825 Da |
| NCBI Full Name: | Inositol hexakisphosphate kinase 2 |
| NCBI Synonym Full Names: | inositol hexakisphosphate kinase 2 |
| NCBI Official Symbol: | IP6K2 |
| NCBI Official Synonym Symbols: | PIUS; IHPK2 |
| NCBI Protein Information: | inositol hexakisphosphate kinase 2 |
| UniProt Protein Name: | Inositol hexakisphosphate kinase 2 |
| UniProt Synonym Protein Names: | P(i)-uptake stimulator; PiUS |
| Protein Family: | Inositol hexakisphosphate kinase |
| UniProt Gene Name: | IP6K2 |
| UniProt Entry Name: | IP6K2_HUMAN |
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