Description
| Product Name: | Human GORASP2 Recombinant Protein |
| Product Code: | RPPB3629 |
| Size: | 20µg |
| Species: | Human |
| Target: | GORASP2 |
| Synonyms: | Golgi reassembly-stacking protein 2, GRS2, Golgi phosphoprotein 6, GOLPH6, Golgi reassembly-stacking protein of 55 kDa, GRASP55, GORASP2, p59, Golgi reassembly-stacking protein 2, isoform 1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The GORASP2 solution (1mg/1ml) contains Phosphate buffered saline (pH7.4). |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMGSSQSV EIPGGGTEGY HVLRVQENSP GHRAGLEPFF DFIVSINGSR LNKDNDTLKD LLKANVEKPV KMLIYSSKTL ELRETSVTPS NLWGGQGLLG VSIRFCSFDG ANENVWHVLE VESNSPAALA GLRPHSDYII GADTVMNESE DLFSLIETHE AKPLKLYVYN TDTDNCREVI ITPNSAWGGE GSLGCGIGYG YLHRIPTRPF EEGKKISLPG QMAGTPITPL KDGFTEVQLS SVNPPSLSPP GTTGIEQSLT GLSISSTPPA VSSVLSTGVP TVPLLPPQVN QSLTSVPPMN PATTLPGLMP LPAGLPNLPN LNLNLPAPHI MPGVGLPELV NPGLPPLPSM PPRNLPGIAP LPLPSEFLPS FPLVPESSSA ASSGELLSSL PPTSNAPSDP ATTTAKADAA SSLTVDVTPP TAKAPTTVED RVGDSTPVSE KPVSAAVDAN ASESP |
GolgiReassembly Stacking Protein 2, also known as GORASP2, takes part in theassembly and membrane stacking of the Golgi cisternae. Furthermore, GORASP2 is aprotein coding gene which regulates the intracellular transport andpresentation of various transmembrane proteins.
GORASP2 Human Recombinant produced in E. coli is a single polypeptide chain containing 475 amino acids (1-452) and having a molecular mass of 49.5kDa.GORASP2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | GRASP55: a golgi reassembly-stacking protein (GRASP) protein involved in the stacking of Golgi cisternae. May be involved in the process by which Golgi stacks reform after mitotic breakdown. May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as the TGF-alpha receptor. Oligomerization of its N-terminal GRASP domain regulates the formation of Golgi stacks, a process that is regulated by phosphorylation within the C-terminal Ser/Pro-rich domain. Forms a RAB2 effector complex with BLZF1 in the medial Golgi. Interacts with members of the p24 cargo receptors. Interacts with CNIH and the cytoplasmic domain of the TGF-alpha receptor, prior its transit in the trans-Golgi. Two alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Vesicle; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 2q31.1 Cellular Component: Golgi membrane; Golgi apparatus; membrane Molecular Function:protein binding Biological Process: organelle organization and biogenesis; mitotic cell cycle |
| NCBI Summary: | This gene encodes a member of the Golgi reassembly stacking protein family. These proteins may play a role in the stacking of Golgi cisternae and Golgi ribbon formation, as well as Golgi fragmentation during apoptosis or mitosis. The encoded protein also plays a role in the intracellular transport of transforming growth factor alpha and may function as a molecular chaperone. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011] |
| UniProt Code: | Q9H8Y8 |
| NCBI GenInfo Identifier: | 51316097 |
| NCBI Gene ID: | 26003 |
| NCBI Accession: | Q9H8Y8.3 |
| UniProt Secondary Accession: | Q9H8Y8,Q53TE3, Q96I74, Q96K84, Q9H946, Q9UFW4, B4DKT0 |
| UniProt Related Accession: | Q9H8Y8 |
| Molecular Weight: | 48,674 Da |
| NCBI Full Name: | Golgi reassembly-stacking protein 2 |
| NCBI Synonym Full Names: | golgi reassembly stacking protein 2, 55kDa |
| NCBI Official Symbol: | GORASP2�� |
| NCBI Official Synonym Symbols: | p59; GRS2; GOLPH6; GRASP55�� |
| NCBI Protein Information: | Golgi reassembly-stacking protein 2; golgi phosphoprotein 6 |
| UniProt Protein Name: | Golgi reassembly-stacking protein 2 |
| UniProt Synonym Protein Names: | Golgi phosphoprotein 6; GOLPH6; Golgi reassembly-stacking protein of 55 kDa; GRASP55; p59 |
| Protein Family: | Golgi reassembly-stacking protein |
| UniProt Gene Name: | GORASP2�� |
| UniProt Entry Name: | GORS2_HUMAN |
