Human FN3K Recombinant Protein (RPPB2535)
- SKU:
- RPPB2535
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- FN3K
- Synonyms:
- Fructosamine-3-kinase
- FN3K
- Source:
- Escherichia Coli
- Uniprot:
- Q9H479
Description
| Product Name: | Human FN3K Recombinant Protein |
| Product Code: | RPPB2535 |
| Size: | 10µg |
| Species: | Human |
| Target: | FN3K |
| Synonyms: | Fructosamine-3-kinase, FN3K. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | FN3K protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMEQLLRA ELRTATLRAF GGPGAGCISE GRAYDTDAGP VFVKVNRRTQ ARQMFEGEVA SLEALRSTGL VRVPRPMKVI DLPGGGAAFV MEHLKMKSLS SQASKLGEQM ADLHLYNQKL REKLKEEENT VGRRGEGAEP QYVDKFGFHT VTCCGFIPQV NEWQDDWPTF FARHRLQAQL DLIEKDYADR EARELWSRLQ VKIPDLFCGL EIVPALLHGD LWSGNVAEDD VGPIIYDPAS FYGHSEFELA IALMFGGFPR SFFTAYHRKI PKAPGFDQRL LLYQLFNYLN HWNHFGREYR SPSLGTMRRL LK |
Fructosamine 3 Kinase (FN3K) catalyzes the phosphorylation of fructosamines which may result in deglycation, the non-enzymatic reaction of glucose with primary amines followed by Amadori re-arrangement. Phosphorylation of fructosamines instigates metabolism of the modified amine and brings about the de-glycation of fructoselysine and of glycated proteins. A high concentration of glucose may affect non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Fructosamines, the proteins altered in this way, are less active or functional.
FN3K Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 332 amino acids (1-309 a.a) and having a molecular mass of 37kDa.FN3K is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | FN3K: May initiate a process leading to the deglycation of fructoselysine and of glycated proteins. May play a role in the phosphorylation of 1-deoxy-1-morpholinofructose (DMF), fructoselysine, fructoseglycine, fructose and glycated lysozyme. Belongs to the fructosamine kinase family. |
| UniProt Protein Details: | Protein type:EC 2.7.1.-; Kinase, other Chromosomal Location of Human Ortholog: 17q25.3 Molecular Function:fructosamine-3-kinase activity Biological Process: fructoselysine metabolic process; epithelial cell differentiation; fructosamine metabolic process; phosphorylation |
| NCBI Summary: | A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way, fructosamines, are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of fructosamines which may result in deglycation. [provided by RefSeq, Feb 2012] |
| UniProt Code: | Q9H479 |
| NCBI GenInfo Identifier: | 11545906 |
| NCBI Gene ID: | 64122 |
| NCBI Accession: | NP_071441.1 |
| UniProt Related Accession: | Q9H479 |
| Molecular Weight: | |
| NCBI Full Name: | fructosamine-3-kinase |
| NCBI Synonym Full Names: | fructosamine 3 kinase |
| NCBI Official Symbol: | FN3K |
| NCBI Protein Information: | fructosamine-3-kinase |
| UniProt Protein Name: | Fructosamine-3-kinase |
| Protein Family: | Fructosamine-3-kinase |
| UniProt Gene Name: | FN3K |
| UniProt Entry Name: | FN3K_HUMAN |
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