Description
| Product Name: | Human FKBP2 Recombinant Protein |
| Product Code: | RPPB1642 |
| Size: | 10µg |
| Species: | Human |
| Target: | FKBP2 |
| Synonyms: | FKBP13, FKBP-2, Peptidyl-prolyl cis-trans isomerase FKBP2, PPIase FKBP2, FK506-binding protein 2, Rotamase, Immunophilin FKBP13, 13 kDa FK506-binding protein, 13 kDa FKBP, FKBP-13, FKBP2, PPIase. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear colorless solution. |
| Formulation: | The FKBP2 solution contains 20mM Tris-HCl pH-8, 1mM DTT, and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MATGAEGKRK LQIGVKKRVD HCPIKSRKGD VLHMHYTGKL EDGTEFDSSL PQNQPFVFSL GTGQVIKGWD QGLLGMCEGE KRKLVIPSEL GYGERGAPPK IPGGATLVFE VELLKIERRT EL |
| Biological Activity: | Specific activity is > 270 nmoles/min/ug, and is defined as the amount of enzyme that cleaves 1umole of suc-AAFP-pNA per minute at 25C in Tris-Hcl pH8.0 using chymotrypsin. |
FKBP2 is part of the immunophilin protein family, which takes part in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP2 is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. FKBP2 functions as an ER chaperone and as a component of membrane cytoskeletal scaffolds.
FKBP2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 122 amino acids (22-142 a.a.) and having a molecular mass of 13.4 kDa. The FKBP2 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | FKBP2: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Belongs to the FKBP-type PPIase family. FKBP2 subfamily. |
| UniProt Protein Details: | Protein type:EC 5.2.1.8; Endoplasmic reticulum; Isomerase Chromosomal Location of Human Ortholog: 11q13.1 Cellular Component: endoplasmic reticulum Molecular Function:FK506 binding; peptidyl-prolyl cis-trans isomerase activity; protein binding |
| NCBI Summary: | The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008] |
| UniProt Code: | P26885 |
| NCBI GenInfo Identifier: | 23503054 |
| NCBI Gene ID: | 2286 |
| NCBI Accession: | P26885.2 |
| UniProt Secondary Accession: | P26885,Q5BJH9, Q9BTS7, |
| UniProt Related Accession: | P26885 |
| Molecular Weight: | 16kDa |
| NCBI Full Name: | Peptidyl-prolyl cis-trans isomerase FKBP2 |
| NCBI Synonym Full Names: | FK506 binding protein 2 |
| NCBI Official Symbol: | FKBP2�� |
| NCBI Official Synonym Symbols: | PPIase; FKBP-13�� |
| NCBI Protein Information: | peptidyl-prolyl cis-trans isomerase FKBP2 |
| UniProt Protein Name: | Peptidyl-prolyl cis-trans isomerase FKBP2 |
| UniProt Synonym Protein Names: | 13 kDa FK506-binding protein; 13 kDa FKBP; FKBP-13; FK506-binding protein 2; FKBP-2; Immunophilin FKBP13; Rotamase |
| Protein Family: | FK506-binding protein |
| UniProt Gene Name: | FKBP2�� |
