Human DNAJB8 Recombinant Protein (RPPB5204)
- SKU:
- RPPB5204
- Product type:
- Recombinant Protein
- Size:
- 25ug
- Species:
- Human
- Target:
- DNAJB8
- Synonyms:
- DnaJ homolog subfamily B member 8
- DNAJB8
- DJ6
- Source:
- Escherichia Coli
- Uniprot:
- Q8NHS0
Description
| Product Name: | Human DNAJB8 Recombinant Protein |
| Product Code: | RPPB5204 |
| Size: | 25µg |
| Species: | Human |
| Target: | DNAJB8 |
| Synonyms: | DnaJ homolog subfamily B member 8, DNAJB8, DJ6. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The DNAJB8 solution (0.25mg/ml) 20mM Tris-HCl buffer (pH8.0), 40% glycerol, 0.15M NaCl and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MANYYEVLGV QASASPEDIK KAYRKLALRW HPDKNPDNKE EAEKKFKLVS EAYEVLSDSK KRSLYDRAGC DSWRAGGGAS TPYHSPFDTG YTFRNPEDIF REFFGGLDPF SFEFWDSPFN SDRGGRGHGL RGAFSAGFGE FPAFMEAFSS FNMLGCSGGS HTTFSSTSFG GSSSGSSGFK SVMSSTEMIN GHKVTTKRIV ENGQERVEVE EDGQLKSVTV NGKEQLKWMD SK |
DnaJ homolog subfamily B member 8 (DNAJB8) is superior suppressors of aggregation and toxicity of disease-associated polyglutamine proteins.DNAJB8 is a member of the DNAJ/HSP40 family of proteins that regulate chaperone activity. DNAJB8 is (de)acetylated at 2 conserved C-terminal lysines which aren’t involved in substrate binding, but do have a role in suppressing protein aggregation. DNAJB8 has been implicated as a cancer-testis antigen and as a cancer stem-like cell antigen involved in renal cell carcinoma.
DNAJB8 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 252 amino acids (1-232 a.a.) and having a molecular mass of 27.8kDa.DNAJB8 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Efficient suppressor of aggregation and toxicity of disease-associated polyglutamine proteins. |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene belongs to the DNAJ/HSP40 family of proteins that regulate chaperone activity. This family member suppresses aggregation and toxicity of polyglutamine proteins, and the C-terminal tail is essential for this activity. It has been implicated as a cancer-testis antigen and as a cancer stem-like cell antigen involved in renal cell carcinoma. [provided by RefSeq, Jun 2012] |
| UniProt Code: | Q8NHS0 |
| NCBI GenInfo Identifier: | 23503241 |
| NCBI Gene ID: | 165721 |
| NCBI Accession: | NP_699161.1 |
| UniProt Secondary Accession: | Q8NHS0,B3KWV7 |
| UniProt Related Accession: | Q8NHS0 |
| Molecular Weight: | 25,686 Da |
| NCBI Full Name: | dnaJ homolog subfamily B member 8 |
| NCBI Synonym Full Names: | DnaJ heat shock protein family (Hsp40) member B8 |
| NCBI Official Symbol: | DNAJB8 |
| NCBI Official Synonym Symbols: | DJ6; CT156 |
| NCBI Protein Information: | dnaJ homolog subfamily B member 8 |
| UniProt Protein Name: | DnaJ homolog subfamily B member 8 |
| UniProt Synonym Protein Names: | |
| Protein Family: | |
| UniProt Gene Name: | DNAJB8 |
| UniProt Entry Name: |
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