Human CTSF Recombinant Protein (RPPB1521)
- SKU:
- RPPB1521
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- CTSF
- Synonyms:
- CATSF
- CLN13
- Cathepsin F
- EC=342241
- Source:
- Escherichia Coli
- Uniprot:
- Q9UBX1
Description
| Product Name: | Human CTSF Recombinant Protein |
| Product Code: | RPPB1521 |
| Size: | 20µg |
| Species: | Human |
| Target: | CTSF |
| Synonyms: | CATSF, CLN13, Cathepsin F, EC=3.4.22.41. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The CTSF solution (1mg/ml) contains 20mM Tris-HCl buffer(pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSAPPEWDW RSKGAVTKVK DQGMCGSCWA FSVTGNVEGQ WFLNQGTLLSLSEQELLDCD KMDKACMGGL PSNAYSAIKN LGGLETEDDY SYQGHMQSCN FSAEKAKVYI NDSVELSQNEQKLAAWLAKR GPISVAINAF GMQFYRHGIS RPLRPLCSPWLIDHAVLLVG YGNRSDVPFW AIKNSWGTDW GEKGYYYLHR GSGACGVNTM ASSAVVD |
Cathepsin F ( CTSF) is a memberof the peptidase C1 family. Cathepsins are papain familycysteine proteinases which are a main component of the lysosomalproteolytic system. The CTSF gene is ubiquitouslyexpressed, and it maps to chromosome 11q13, close to the gene encodingcathepsin W. CTSF plays a role in normal protein catabolism. CTSF involved in somedegradative processes occurring in tumor progression since it is highlyexpressed in some cancer cell lines.
CTSF Human Recombinant produced in E.coli is a single,non-glycosylated polypeptide chain containing 237 amino acids (271-484) andhaving a molecular mass of 26kDa.CTSF is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CTSF: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. Belongs to the peptidase C1 family. |
| UniProt Protein Details: | Protein type:EC 3.4.22.41; Protease Chromosomal Location of Human Ortholog: 11q13 Cellular Component: extracellular space; lysosomal lumen; lysosome Molecular Function:cysteine-type endopeptidase activity Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; proteolysis; proteolysis involved in cellular protein catabolic process Disease: Ceroid Lipofuscinosis, Neuronal, 13 |
| NCBI Summary: | Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UBX1 |
| NCBI GenInfo Identifier: | 12643325 |
| NCBI Gene ID: | 8722 |
| NCBI Accession: | Q9UBX1.1 |
| UniProt Secondary Accession: | Q9UBX1,O95240, Q9NSU4, Q9UKQ5, B2R964, |
| UniProt Related Accession: | Q9UBX1 |
| Molecular Weight: | 53,366 Da |
| NCBI Full Name: | Cathepsin F |
| NCBI Synonym Full Names: | cathepsin F |
| NCBI Official Symbol: | CTSF |
| NCBI Official Synonym Symbols: | CATSF; CLN13 |
| NCBI Protein Information: | cathepsin F |
| UniProt Protein Name: | Cathepsin F |
| Protein Family: | Cathepsin |
| UniProt Gene Name: | CTSF |
| UniProt Entry Name: | CATF_HUMAN |
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