Human CLNS1A Recombinant Protein (RPPB3207)
- SKU:
- RPPB3207
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- CLNS1A
- Synonyms:
- CLNS1A
- CLCI
- ICLN
- CLNS1B
- Source:
- Escherichia Coli
- Uniprot:
- P54105
Description
| Product Name: | Human CLNS1A Recombinant Protein |
| Product Code: | RPPB3207 |
| Size: | 20µg |
| Species: | Human |
| Target: | CLNS1A |
| Synonyms: | CLNS1A, CLCI, ICLN, CLNS1B, Methylosome subunit pICln, Chloride channel, nucleotide sensitive 1A, Chloride conductance regulatory protein ICln, Chloride ion current inducer protein, Reticulocyte pICln. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The CLNS1A solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 10% glycerol and 2mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMSFLKS FPPPGPAEGL LRQQPDTEAV LNGKGLGTGT LYIAESRLSW LDGSGLGFSL EYPTISLHAL SRDRSDCLGE HLYVMVNAKF EEESKEPVAD EEEEDSDDDV EPITEFRFVP SDKSALEAMF TAMCECQALH PDPEDEDSDD YDGEEYDVEA HEQGQGDIPT FYTYEEGLSH LTAEGQATLE RLEGMLSQSV SSQYNMAGVR TEDSIRDYED GMEVDTTPTV AGQFEDADVD H |
Methylosome subunit pICln (CLNS1A), is a member of the pICln (TC 1.A.47) family. CLNS1A takes part in multiple regulatory pathways. CLNS1A interaction with Sm proteins, inhibits their compilation on U RNA and interferes with snRNP biogenesis. CLNS1A inhibits the binding of survival motor neuron protein (SMN) to Sm proteins. Methylosome subunit pICln is related with the plasma membrane where it functions as a chloride present regulator.
CLNS1A Human Recombinant produced in E. coli is a single polypeptide chain containing 261 amino acids (1-237) and having a molecular mass of 28.8kDa (molecular size on SDS-PAGE will appear higher).CLNS1A is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ICLN: The interaction with Sm proteins inhibits their assembly on U RNA and interferes with snRNP biogenesis. Inhibits the binding of survival motor neuron protein (SMN) to Sm proteins. May participate in cellular volume control by activation of a swelling-induced chloride conductance pathway. Belongs to the pICln (TC 1.A.47) family. |
| UniProt Protein Details: | Protein type:Channel, chloride Chromosomal Location of Human Ortholog: 11q13.5-q14 Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus Molecular Function:protein binding; protein heterodimerization activity Biological Process: spliceosomal snRNP biogenesis |
| NCBI Summary: | This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015] |
| UniProt Code: | P54105 |
| NCBI GenInfo Identifier: | 1708393 |
| NCBI Gene ID: | 1207 |
| NCBI Accession: | P54105.1 |
| UniProt Secondary Accession: | P54105,Q0VDK6, Q9NRD2, Q9NRD3, B2RCS9, |
| UniProt Related Accession: | P54105 |
| Molecular Weight: | 26,215 Da |
| NCBI Full Name: | Methylosome subunit pICln |
| NCBI Synonym Full Names: | chloride nucleotide-sensitive channel 1A |
| NCBI Official Symbol: | CLNS1A |
| NCBI Official Synonym Symbols: | CLCI; ICln; CLNS1B |
| NCBI Protein Information: | methylosome subunit pICln |
| UniProt Protein Name: | Methylosome subunit pICln |
| UniProt Synonym Protein Names: | Chloride channel, nucleotide sensitive 1A; Chloride conductance regulatory protein ICln; I(Cln); Chloride ion current inducer protein; ClCI; Reticulocyte pICln |
| UniProt Gene Name: | CLNS1A |
| UniProt Entry Name: | ICLN_HUMAN |
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