Human CIRBP Recombinant Protein (RPPB3187)
- SKU:
- RPPB3187
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- CIRBP
- Synonyms:
- Cold-inducible RNA-binding protein
- A18 hnRNP
- Glycine-rich RNA-binding protein CIRP
- CIRBP
- Source:
- Escherichia Coli
- Uniprot:
- Q14011
Frequently bought together:
Description
| Product Name: | Human CIRBP Recombinant Protein |
| Product Code: | RPPB3187 |
| Size: | 20µg |
| Species: | Human |
| Target: | CIRBP |
| Synonyms: | Cold-inducible RNA-binding protein, A18 hnRNP, Glycine-rich RNA-binding protein CIRP, CIRBP, A18HNRNP, CIRP. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | CIRBP protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 50% glycerol and 0.1M NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MASDEGKLFV GGLSFDTNEQ SLEQVFSKYG QISEVVVVKD RETQRSRGFG FVTFENIDDA KDAMMAMNGK SVDGRQIRVD QAGKSSDNRS RGYRGGSAGG RGFFRGGRGR GRGFSRGGGD RGYGGNRFES RSGGYGGSRD YYSSRSQSGG YSDRSSGGSY RDSYDSYATH NE |
Cold inducible RNA-binding protein (CIRBP) has a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. CIRBP localizes to the nucleus and contains one RRM (RNA recognition motif) domain. Expressed ubiquitously, CIRBP is believed to play a crucial role in the suppression of cellular proliferation in response to UV irradiation or extreme cold.
CIRBP produced in E.Coli is a single, non-glycosylated polypeptide chain containing 192 amino acids (1-172 a.a.) and having a molecular mass of 20.8kDa.CIRBP is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor. Promotes assembly of stress granules (SGs), when overexpressed. |
| UniProt Code: | Q14011 |
| NCBI GenInfo Identifier: | 5921786 |
| NCBI Gene ID: | 1153 |
| NCBI Accession: | Q14011.1 |
| UniProt Secondary Accession: | Q14011,B3KT17, B4E2X2, |
| UniProt Related Accession: | Q14011 |
| Molecular Weight: | 19kDa |
| NCBI Full Name: | Cold-inducible RNA-binding protein |
| NCBI Synonym Full Names: | cold inducible RNA binding protein |
| NCBI Official Symbol: | CIRBP |
| NCBI Official Synonym Symbols: | CIRP |
| NCBI Protein Information: | cold-inducible RNA-binding protein |
| UniProt Protein Name: | Cold-inducible RNA-binding protein |
| UniProt Synonym Protein Names: | A18 hnRNP; Glycine-rich RNA-binding protein CIRP |
| Protein Family: | Cold-inducible RNA-binding protein |
| UniProt Gene Name: | CIRBP |
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