Human CDK3 Recombinant Protein (RPPB2461)
- SKU:
- RPPB2461
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- CDK3
- Synonyms:
- Cyclin-dependent kinase 3
- Cell division protein kinase 3
- CDK3
- CDKN3
- Source:
- Escherichia Coli
- Uniprot:
- Q00526
Description
| Product Name: | Human CDK3 Recombinant Protein |
| Product Code: | RPPB2461 |
| Size: | 10µg |
| Species: | Human |
| Target: | CDK3 |
| Synonyms: | Cyclin-dependent kinase 3, Cell division protein kinase 3, CDK3, CDKN3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The CDK3 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMDMFQKV EKIGEGTYGV VYKAKNRETG QLVALKKIRL DLEMEGVPST AIREISLLKE LKHPNIVRLL DVVHNERKLY LVFEFLSQDL KKYMDSTPGS ELPLHLIKSY LFQLLQGVSF CHSHRVIHRD LKPQNLLINE LGAIKLADFG LARAFGVPLR TYTHEVVTLW YRAPEILLGS KFYTTAVDIW SIGCIFAEMV TRKALFPGDS EIDQLFRIFR MLGTPSEDTW PGVTQLPDYK GSFPKWTRKG LEEIVPNLEP EGRDLLMQLL QYDPSQRITA KTALAHPYFS SPEPSPAARQ YVLQRFRH |
Cyclin-dependent kinase 3, also known as CDK3, is a part of the cyclin-dependent protein kinase family. CDK3 promotes entry into S phase, partially by activating members of the E2F family of transcription factors. CDK3 also associates with cyclin C and phosphorylates the retinoblastoma one protein to promote exit from G0.
CDK3 Human Recombinant produced in E. coli is a single polypeptide chain containing 328 amino acids (1-305) and having a molecular mass of 37.4kDa.CDK3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CDK3: a protein kinase of the CDK family. May be involved in cell cycle control. Can phosphorylate histone H1. |
| UniProt Protein Details: | Protein type:Kinase, protein; Cell cycle regulation; Protein kinase, CMGC; EC 2.7.11.22; Protein kinase, Ser/Thr (non-receptor); CMGC group; CDK family; CDK/CDK1 subfamily; CDK1 subfamily Chromosomal Location of Human Ortholog: 17q25.1 Biological Process: cell proliferation; G0 to G1 transition; G1/S transition of mitotic cell cycle; response to DNA damage stimulus |
| NCBI Summary: | This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q00526 |
| NCBI GenInfo Identifier: | 231726 |
| NCBI Gene ID: | 1018 |
| NCBI Accession: | Q00526.1 |
| UniProt Related Accession: | Q00526 |
| Molecular Weight: | 35,046 Da |
| NCBI Full Name: | Cyclin-dependent kinase 3 |
| NCBI Synonym Full Names: | cyclin dependent kinase 3 |
| NCBI Official Symbol: | CDK3 |
| NCBI Protein Information: | cyclin-dependent kinase 3 |
| UniProt Protein Name: | Cyclin-dependent kinase 3 |
| UniProt Synonym Protein Names: | Cell division protein kinase 3 |
| Protein Family: | Cyclin-dependent kinase |
| UniProt Gene Name: | CDK3 |
| UniProt Entry Name: | CDK3_HUMAN |
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