Description
| Product Name: | Human CD37 Recombinant Protein |
| Product Code: | RPPB3070 |
| Size: | 20µg |
| Species: | Human |
| Target: | CD37 |
| Synonyms: | GP52-40, TSPAN26, Leukocyte antigen CD37, Tetraspanin-26,Tspan-26. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | CD37 protein solution (1mg/ml) containing Phosphatebuffer saline, (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSQRAQLER SLRDVVEKTI QKYGTNPEET AAEESWDYVQ FQLRCCGWHYPQDWFQVLIL RGNGSEAHRV PCSCYNLSAT NDSTILDKVI LPQLSRLGHL ARSRHSADIC AVPAESHIYREGCAQGLQKW LHNN |
CD37 belongs to the transmembrane 4 superfamily, otherwise known as the tetraspanin family. Most of its members are cell-surface proteins which are distinguished by the presence of 4 hydrophobic domains. These proteins mediate signal transduction events which have a role in the regulation of cell development, activation, growth and motility. CD37 protein is a cell surface glycoprotein which is known to form complexes with integrins and other transmembrane 4 superfamily proteins. CD37 may also havea role in T-cell-B-cell interactions.
CD37 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 154 amino acids (112-241 a.a) and having a molecular mass of 17.4kDa.CD37 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CD37: is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: immunological synapse; integral to plasma membrane; membrane Molecular Function:protein binding Biological Process: cell surface receptor linked signal transduction |
| NCBI Summary: | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P11049 |
| NCBI GenInfo Identifier: | 115983 |
| NCBI Gene ID: | 951 |
| NCBI Accession: | P11049.2 |
| UniProt Secondary Accession: | P11049,Q3KPF9, B4DVC1, |
| UniProt Related Accession: | P11049 |
| Molecular Weight: | 22,563 Da |
| NCBI Full Name: | Leukocyte antigen CD37 |
| NCBI Synonym Full Names: | CD37 molecule |
| NCBI Official Symbol: | CD37�� |
| NCBI Official Synonym Symbols: | GP52-40; TSPAN26�� |
| NCBI Protein Information: | leukocyte antigen CD37 |
| UniProt Protein Name: | Leukocyte antigen CD37 |
| UniProt Synonym Protein Names: | Tetraspanin-26; Tspan-26; CD_antigen: CD37 |
| Protein Family: | Leukocyte antigen |
| UniProt Gene Name: | CD37�� |
| UniProt Entry Name: | CD37_HUMAN |
