Human CAPG Recombinant Protein (RPPB5868)
- SKU:
- RPPB5868
- Product type:
- Recombinant Protein
- Size:
- 25ug
- Species:
- Human
- Target:
- CAPG
- Synonyms:
- AFCP
- CAPG
- Macrophage-capping protein
- Actin regulatory protein CAP-G
- Source:
- Escherichia Coli
- Uniprot:
- P40121
Description
| Product Name: | Human CAPG Recombinant Protein |
| Product Code: | RPPB5868 |
| Size: | 25µg |
| Species: | Human |
| Target: | CAPG |
| Synonyms: | AFCP, CAPG, Macrophage-capping protein, Actin regulatory protein CAP-G, MCP. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The protein solution (1mg/ml) contains 20mM Tris buffer pH-8, 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MYTAIPQSGS PFPGSVQDPG LHVWRVEKLK PVPVAQENQG VFFSGDSYLV LHNGPEEVSH LHLWIGQQSS RDEQGACAVL AVHLNTLLGE RPVQHREVQG NESDLFMSYF PRGLKYQEGG VESAFHKTST GAPAAIKKLY QVKGKKNIRA TERALNWDSF NTGDCFILDL GQNIFAWCGG KSNILERNKA RDLALAIRDS ERQGKAQVEI VTDGEEPAEM IQVLGPKPAL KEGNPEEDLT ADKANAQAAA LYKVSDATGQ MNLTKVADSS PFALELLISD DCFVLDNGLC GKIYIWKGRK ANEKERQAAL QVAEGFISRM QYAPNTQVEI LPQGRESPIF KQFFKDWK |
CAPG is part of the gelsolin/villin family of actin-regulatory proteins. CAPG reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated method, though it does not separate preformed actin filaments. By capping the barbed ends of actin filaments, CAPG contributes to the control of actin-based motility in non-muscle cells. CAPG is involved in macrophage function. CAPG is involved in regulating cytoplasmic and/or nuclear structures via possible interactions with actin. CAPG binds DNA. CAPG lacks a nuclear export sequence present in structurally related proteins. CAPG is a tumor suppressor protein that plays a role in the tumorigenic progression of certain cancers. Dysregulated expression of CAPG was found in premalignant and malignant oral carcinogenesis.
CAPG Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 348 amino acids (1-348 a.a.) and having a molecular mass of 38.5 kDa. The CAPG protein is purified by standard chromatography techniques.
| UniProt Protein Function: | CAPG: Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA. Belongs to the villin/gelsolin family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 2p11.2 Cellular Component: F-actin capping protein complex; melanosome; nucleus Molecular Function:actin binding Biological Process: protein complex assembly; cell projection biogenesis; barbed-end actin filament capping |
| NCBI Summary: | This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2012] |
| UniProt Code: | P40121 |
| NCBI GenInfo Identifier: | 313104088 |
| NCBI Gene ID: | 822 |
| NCBI Accession: | P40121.2 |
| UniProt Secondary Accession: | P40121,Q53SA7, B8ZZS7, D6W5K8, |
| UniProt Related Accession: | P40121 |
| Molecular Weight: | 348 |
| NCBI Full Name: | Macrophage-capping protein |
| NCBI Synonym Full Names: | capping protein (actin filament), gelsolin-like |
| NCBI Official Symbol: | CAPG |
| NCBI Official Synonym Symbols: | MCP; AFCP; HEL-S-66 |
| NCBI Protein Information: | macrophage-capping protein; macrophage capping protein; gelsolin-like capping protein; actin regulatory protein CAP-G; actin-regulatory protein CAP-G; epididymis secretory protein Li 66 |
| UniProt Protein Name: | Macrophage-capping protein |
| UniProt Synonym Protein Names: | Actin regulatory protein CAP-G |
| Protein Family: | Protein |
| UniProt Gene Name: | CAPG |
| UniProt Entry Name: | CAPG_HUMAN |
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