Description
| Product Name: | Human CAMK2N2 Recombinant Protein |
| Product Code: | RPPB2449 |
| Size: | 20µg |
| Species: | Human |
| Target: | CAMK2N2 |
| Synonyms: | Calcium/calmodulin-dependent protein kinase II inhibitor 2, CAMK2N2, CaM-KII inhibitory protein, CaM-KIIN, CAMKIIN, Calcium/calmodulin-dependent protein kinase II. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | CAMK2N2 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 0.15M NaCl, 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMSEILPY SEDKMGRFGA DPEGSDLSFS CRLQDTNSFF AGNQAKRPPK LGQIGRAKRV VIEDDRIDDV LKGMGEKPPS GV |
Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor 2 (CAMK2N2) is a protein coding gene which regulates cell growth when overexpressed in colon adenocarcinoma LoVo cells. CAMK2N2 plays a role as a cellular inhibitor of CaM-kinase II (CAMK2).
CAMK2N2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 102 amino acids (1-79a.a) and having a molecular mass of 11kDa.CAMK2N2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CAMK2N2: Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2. May play an important role in the regulation of cell growth when overexpressed in colon adenocarcinoma LoVo cells. Traps Ca(2+)/calmodulin on CAMK2. Belongs to the CAMK2N family. |
| UniProt Protein Details: | Protein type:Protein kinase, regulatory subunit; Inhibitor Chromosomal Location of Human Ortholog: 3q27.1 Cellular Component: centrosome; cytosol; nucleus Molecular Function:calcium-dependent protein kinase inhibitor activity; protein kinase binding |
| NCBI Summary: | This gene encodes a protein that is highly similar to the rat CaM-KII inhibitory protein, an inhibitor of calcium/calmodulin-dependent protein kinase II (CAMKII). CAMKII regulates numerous physiological functions, including neuronal synaptic plasticity through the phosphorylation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate (AMPA) receptors. Studies of the similar protein in rat suggest that this protein may function as a negative regulator of CaM-KII and may act to inhibit the phosphorylation of AMPA receptors. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96S95 |
| NCBI GenInfo Identifier: | 15147234 |
| NCBI Gene ID: | 94032 |
| NCBI Accession: | NP_150284.1 |
| UniProt Related Accession: | Q96S95 |
| Molecular Weight: | 8,658 Da |
| NCBI Full Name: | calcium/calmodulin-dependent protein kinase II inhibitor 2 |
| NCBI Synonym Full Names: | calcium/calmodulin dependent protein kinase II inhibitor 2 |
| NCBI Official Symbol: | CAMK2N2�� |
| NCBI Official Synonym Symbols: | CAMKIIN; CAM-KIIN�� |
| NCBI Protein Information: | calcium/calmodulin-dependent protein kinase II inhibitor 2 |
| UniProt Protein Name: | Calcium/calmodulin-dependent protein kinase II inhibitor 2 |
| UniProt Synonym Protein Names: | CaM-KII inhibitory protein; CaM-KIIN |
| Protein Family: | Calcium/calmodulin-dependent protein kinase II inhibitor |
| UniProt Gene Name: | CAMK2N2�� |
| UniProt Entry Name: | CK2N2_HUMAN |
