Human CALN1 Recombinant Protein (RPPB2968)
- SKU:
- RPPB2968
- Product type:
- Recombinant Protein
- Size:
- 5ug
- Species:
- Human
- Target:
- CALN1
- Synonyms:
- Calcium-binding protein 8
- CaBP8
- Calneuron I
- Calneuron-1
- Source:
- Escherichia Coli
- Uniprot:
- Q9BXU9
Description
| Product Name: | Human CALN1 Recombinant Protein |
| Product Code: | RPPB2968 |
| Size: | 5µg |
| Species: | Human |
| Target: | CALN1 |
| Synonyms: | Calcium-binding protein 8, CaBP8, Calneuron I, Calneuron-1, CALN1, CABP8. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The CALN1 solution (0.5 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 10% glycerol, 2mM DTT, 50mM NaCl and 0.1mM PMSF. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MPFHHVTAGL LYKGNYLNRS LSAGSDSEQL ANISVEELDE IREAFRVLDR DGNGFISKQE LGMAMRSLGY MPSEVELAII MQRLDMDGDG QVDFDEFMTI LGPKLVSSEG RDGFLGNTID SIFWQFDMQR ITLEELKHIL YHAFRDHLTM KDIENIIINE EESLNETSGN CQTEFEGVHS QKQNRQTCVR KS |
CALN1 is highly similar to the calcium-binding proteins of the calmodulin family. The CALN1 protein contains two EF-hand domains and potential calcium-binding sites. Also, CALN1 negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. CALN1 has a role in the physiology of neurons and is potentially significant in memory and learning.
CALN1 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 212 amino acids (1-192 a.a.) and having a molecular mass of 24kDa. The CALN1 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CALN1: Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. May play a role in the physiology of neurons and is potentially important in memory and learning. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 7q11 Cellular Component: perinuclear region of cytoplasm; plasma membrane; integral to membrane; trans-Golgi network membrane Molecular Function:calcium ion binding |
| NCBI Summary: | This gene encodes a protein with high similarity to the calcium-binding proteins of the calmodulin family. The encoded protein contains two EF-hand domains and potential calcium-binding sites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9BXU9 |
| NCBI GenInfo Identifier: | 20177867 |
| NCBI Gene ID: | 83698 |
| NCBI Accession: | Q9BXU9.1 |
| UniProt Secondary Accession: | Q9BXU9,J3KQA7, |
| UniProt Related Accession: | Q9BXU9 |
| Molecular Weight: | 29,324 Da |
| NCBI Full Name: | Calcium-binding protein 8 |
| NCBI Synonym Full Names: | calneuron 1 |
| NCBI Official Symbol: | CALN1 |
| NCBI Official Synonym Symbols: | CABP8 |
| NCBI Protein Information: | calcium-binding protein 8; calcium-binding protein CABP8; calneuron I; calneuron-1 |
| UniProt Protein Name: | Calcium-binding protein 8 |
| UniProt Synonym Protein Names: | Calneuron I; Calneuron-1 |
| Protein Family: | Calcium-binding protein |
| UniProt Gene Name: | CALN1 |
| UniProt Entry Name: | CABP8_HUMAN |
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