Human BEX1 Recombinant Protein (RPPB2885)
- SKU:
- RPPB2885
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- BEX1
- Synonyms:
- BEX2
- HBEX2
- HGR74-h
- Protein BEX1
- Source:
- Escherichia Coli
- Uniprot:
- Q9HBH7
Frequently bought together:
Description
| Product Name: | Human BEX1 Recombinant Protein |
| Product Code: | RPPB2885 |
| Size: | 10µg |
| Species: | Human |
| Target: | BEX1 |
| Synonyms: | BEX2, HBEX2, HGR74-h, Protein BEX1, Brain-expressed X-linked protein 1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The BEX1 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl and 30% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 80% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMESKEKR AVNSLSMENA NQENEEKEQV ANKGEPLALP LDAGEYCVPR GNRRRFRVRQ PILQYRWDMM HRLGEPQARM REENMERIGE EVRQLMEKLR EKQLSHSLRA VSTDPPHHDH HDEFCLMP |
Brain Expressed X-Linked 1 (BEX1) which participates in cell cycle progression and neuronal differentiation, is a signaling adapter molecule involved in p75NTR/NGFR signaling. BEX1 inhibits neuronal differentiation in response to nerve growth factor. BEX1 links between the cell cycle and neurotrophic factor signaling by acting as an upstream modulator of receptor signaling, adjusting biological responses to external signals with internal cellular states.
BEX1 Human Recombinant produced in E. coli is a single polypeptide chain containing 148 amino acids (1-125) and having a molecular mass of 17.2kDa. BEX1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | BEX1: Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states. Belongs to the BEX family.Protein type: Cell development/differentiation; Cell cycle regulationChromosomal Location of Human Ortholog: Xq22.1|Xq22Cellular Component: transcription factor complexMolecular Function: protein bindingBiological Process: positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9HBH7 |
| NCBI GenInfo Identifier: | 91208332 |
| NCBI Gene ID: | 55859 |
| NCBI Accession: | Q9HBH7.2 |
| UniProt Secondary Accession: | Q9HBH7,Q9NZ33, A0AVN1, A8K4J3 |
| UniProt Related Accession: | Q9HBH7 |
| Molecular Weight: | 14,860 Da |
| NCBI Full Name: | Protein BEX1 |
| NCBI Synonym Full Names: | brain expressed X-linked 1 |
| NCBI Official Symbol: | BEX1 |
| NCBI Official Synonym Symbols: | BEX2; HBEX2; HGR74-h |
| NCBI Protein Information: | protein BEX1 |
| UniProt Protein Name: | Protein BEX1 |
| UniProt Synonym Protein Names: | Brain-expressed X-linked protein 1 |
| Protein Family: | Protein |
| UniProt Gene Name: | BEX1 |
| UniProt Entry Name: | BEX1_HUMAN |
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