Human ATP5O Recombinant Protein (RPPB1428)
- SKU:
- RPPB1428
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- ATP5O
- Synonyms:
- ATP synthase subunit O mitochondrial
- Oligomycin sensitivity conferral protein
- OSCP
- ATP5O
- Source:
- Escherichia Coli
- Uniprot:
- P48047
Description
| Product Name: | Human ATP5O Recombinant Protein |
| Product Code: | RPPB1428 |
| Size: | 20µg |
| Species: | Human |
| Target: | ATP5O |
| Synonyms: | ATP synthase subunit O mitochondrial, Oligomycin sensitivity conferral protein, OSCP, ATP5O, ATPO. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The ATP5O solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 40% glycerol and 0.2M NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MFAKLVRPPV QVYGIEGRYA TALYSAASKQ NKLEQVEKEL LRVAQILKEP KVAASVLNPY VKRSIKVKSL NDITAKERFS PLTTNLINLL AENGRLSNTQ GVVSAFSTMM SVHRGEVPCT VTSASPLEEA TLSELKTVLK SFLSQGQVLK LEAKTDPSIL GGMIVRIGEK YVDMSVKTKI QKLGRAMREI V |
ATP synthase subunit O (ATP5O) localizes to the mitochondria and catalyzes ATP synthesis. ATP5O is a component of the F-type ATPase found in the mitochondrial matrix. F-type ATPases are composed of a catalytic core and a membrane proton channel. ATP5O seems to be part of the connector connecting these two components and may be involved in transmission of conformational changes or proton conductance.
ATP5O Human Recombinant fused with a 21 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 211 amino acids (24-213 a.a.) and having a molecular mass of 23.1kDa. The ATP5O is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ATP5O: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Belongs to the ATPase delta chain family. |
| UniProt Protein Details: | Protein type:Energy Metabolism - oxidative phosphorylation; EC 3.6.3.14; Hydrolase; Mitochondrial Chromosomal Location of Human Ortholog: 21q22.11 Cellular Component: mitochondrial inner membrane; mitochondrial proton-transporting ATP synthase complex; mitochondrion; nucleus; plasma membrane Molecular Function:ATPase activity; drug binding; protein binding; transmembrane transporter activity Biological Process: ATP biosynthetic process; mitochondrial ATP synthesis coupled proton transport |
| NCBI Summary: | The protein encoded by this gene is a component of the F-type ATPase found in the mitochondrial matrix. F-type ATPases are composed of a catalytic core and a membrane proton channel. The encoded protein appears to be part of the connector linking these two components and may be involved in transmission of conformational changes or proton conductance. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P48047 |
| NCBI GenInfo Identifier: | 1352049 |
| NCBI Gene ID: | 539 |
| NCBI Accession: | P48047.1 |
| UniProt Secondary Accession: | P48047,Q5U042, Q6IBI2, B2R4E2, |
| UniProt Related Accession: | P48047 |
| Molecular Weight: | 23,277 Da |
| NCBI Full Name: | ATP synthase subunit O, mitochondrial |
| NCBI Synonym Full Names: | ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit |
| NCBI Official Symbol: | ATP5O |
| NCBI Official Synonym Symbols: | ATPO; OSCP; HMC08D05 |
| NCBI Protein Information: | ATP synthase subunit O, mitochondrial |
| UniProt Protein Name: | ATP synthase subunit O, mitochondrial |
| UniProt Synonym Protein Names: | Oligomycin sensitivity conferral protein; OSCP |
| UniProt Gene Name: | ATP5O |
| UniProt Entry Name: | ATPO_HUMAN |
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