Description
| Product Name: | Human AITR Recombinant Protein |
| Product Code: | RPPB0029 |
| Size: | 10µg |
| Species: | Human |
| Target: | AITR |
| Synonyms: | TNFRSF18, AITR, CD357, GITR, GITR-D, Tumor necrosis factor receptor superfamily member 18, Activation-inducible TNFR family receptor, Glucocorticoid-induced TNFR-related protein, CD357, UNQ319/PRO364. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | AITR protein solution (0.5mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | QRPTGGPGCG PGRLLLGTGT DARCCRVHTT RCCRDYPGEE CCSEWDCMCV QPEFHCGDPC CTTCRHHPCP PGQGVQSQGK FSFGFQCIDC ASGTFSGGHE GHCKPWTDCT QFGFLTVFPG NKTHNAVCVP GSPPAEPLEH HHHHH |
Tumor necrosis factor receptor superfamily member 18 (AITR) is a member of the tumor necrosis factor receptor superfamily. AITR is receptor for TNFSF18 and appears to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. AITR is mediates NF-kappa-B activation via the TRAF2/NIK pathway.
AITR Human Recombinant produced in Sf9 Baculovirus is a single, glycosylated polypeptide chain containing 145 amino acids (26-162a.a.) and having a molecular mass of 15.6kDa (Migrates at 18-28kDa on SDS-PAGE under reducing conditions).AITR is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TNFRSF18: Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, cytokine; Apoptosis Chromosomal Location of Human Ortholog: 1p36.3 Cellular Component: external side of plasma membrane; extracellular region; integral to plasma membrane; plasma membrane Molecular Function:tumor necrosis factor receptor activity Biological Process: immune response; induction of apoptosis via death domain receptors; inflammatory response; multicellular organismal development; negative regulation of apoptosis; positive regulation of cell adhesion; positive regulation of leukocyte migration; positive regulation of tyrosine phosphorylation of Stat1 protein; regulation of cell proliferation; response to lipopolysaccharide; signal transduction; tumor necrosis factor-mediated signaling pathway |
| NCBI Summary: | This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011] |
| UniProt Code: | Q9Y5U5 |
| NCBI GenInfo Identifier: | 13878830 |
| NCBI Gene ID: | 8784 |
| NCBI Accession: | Q9Y5U5.1 |
| UniProt Secondary Accession: | Q9Y5U5,O95851, Q5U0I4, Q9NYJ9, B1AME1, |
| UniProt Related Accession: | Q9Y5U5 |
| Molecular Weight: | 25,110 Da |
| NCBI Full Name: | Tumor necrosis factor receptor superfamily member 18 |
| NCBI Synonym Full Names: | tumor necrosis factor receptor superfamily member 18 |
| NCBI Official Symbol: | TNFRSF18�� |
| NCBI Official Synonym Symbols: | AITR; GITR; CD357; GITR-D�� |
| NCBI Protein Information: | tumor necrosis factor receptor superfamily member 18 |
| UniProt Protein Name: | Tumor necrosis factor receptor superfamily member 18 |
| UniProt Synonym Protein Names: | Activation-inducible TNFR family receptor; Glucocorticoid-induced TNFR-related protein; CD_antigen: CD357 |
| UniProt Gene Name: | TNFRSF18�� |
| UniProt Entry Name: | TNR18_HUMAN |
