| UniProt Protein Function: | GSTT1: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide. Belongs to the GST superfamily. Theta family. |
| UniProt Protein Details: | Protein type:Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450; Other Amino Acids Metabolism - glutathione; Transferase; EC 2.5.1.18 Chromosomal Location of Human Ortholog: 22q11.23 Cellular Component: cytosol Molecular Function:glutathione peroxidase activity; glutathione transferase activity Biological Process: glutathione metabolic process |
| NCBI Summary: | The protein encoded by this gene, glutathione S-transferase (GST) theta 1 (GSTT1), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT1 and GSTT2/GSTT2B share 55% amino acid sequence identity and may play a role in human carcinogenesis. The GSTT1 gene is haplotype-specific and is absent from 38% of the population. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2015] |
| UniProt Code: | P30711 |
| NCBI GenInfo Identifier: | 21264427 |
| NCBI Gene ID: | 2952 |
| NCBI Accession: | P30711.4 |
| UniProt Secondary Accession: | P30711,O00226, Q5TZY2, Q6IC69, Q969K8, Q96IY3, |
| UniProt Related Accession: | P30711 |
| Molecular Weight: | 13,517 Da |
| NCBI Full Name: | Glutathione S-transferase theta-1 |
| NCBI Synonym Full Names: | glutathione S-transferase theta 1 |
| NCBI Official Symbol: | GSTT1 |
| NCBI Protein Information: | glutathione S-transferase theta-1 |
| UniProt Protein Name: | Glutathione S-transferase theta-1 |
| UniProt Synonym Protein Names: | GST class-theta-1; Glutathione transferase T1-1 |
| Protein Family: | Glutathione S-transferase |
| UniProt Gene Name: | GSTT1 |
| UniProt Entry Name: | GSTT1_HUMAN |
