| UniProt Protein Function: | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H (). |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes the pore-forming alpha subunit of a voltage gated calcium channel. The encoded protein is a member of a subfamily of calcium channels referred to as is a low voltage-activated, T-type, calcium channel. The channel encoded by this protein is characterized by a slower activation and inactivation compared to other T-type calcium channels. This protein may be involved in calcium signaling in neurons. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011] |
| UniProt Code: | Q9P0X4 |
| NCBI GenInfo Identifier: | 51093859 |
| NCBI Gene ID: | 8911 |
| NCBI Accession: | NP_001003406.1 |
| UniProt Secondary Accession: | Q9P0X4,O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15 Q9UH30, Q9ULU9, B0QY12 |
| UniProt Related Accession: | Q9P0X4 |
| Molecular Weight: | 241,448 Da |
| NCBI Full Name: | voltage-dependent T-type calcium channel subunit alpha-1I isoform b |
| NCBI Synonym Full Names: | calcium voltage-gated channel subunit alpha1 I |
| NCBI Official Symbol: | CACNA1I |
| NCBI Official Synonym Symbols: | Cav3.3; ca(v)3.3 |
| NCBI Protein Information: | voltage-dependent T-type calcium channel subunit alpha-1I |
| UniProt Protein Name: | Voltage-dependent T-type calcium channel subunit alpha-1I |
| UniProt Synonym Protein Names: | Voltage-gated calcium channel subunit alpha Cav3.3; Ca(v)3.3 |
| Protein Family: | |
| UniProt Gene Name: | CACNA1I |
| UniProt Entry Name: | |
