The UGT2B17 polyclonal antibody (CAB20683) is an essential tool for researchers studying the UGT2B17 enzyme, an important phase II drug-metabolizing enzyme responsible for the glucuronidation of various endogenous compounds and xenobiotics. This antibody, produced in rabbits, is highly specific to human UGT2B17 and is validated for use in Western blot applications. By binding to the UGT2B17 enzyme, this antibody allows for precise detection and analysis in a range of cell types, making it an invaluable asset for studies in drug metabolism, pharmacokinetics, and personalized medicine.
UGT2B17 is known for its role in the metabolism of steroid hormones, environmental toxins, and drugs, making it a key player in the body's detoxification processes. Dysregulation of UGT2B17 activity has been linked to various diseases and conditions, including hormone-related cancers, drug toxicity, and metabolic disorders. By understanding the function and regulation of UGT2B17, researchers can gain insights into potential therapeutic targets and personalized treatment approaches for individuals with altered enzyme activity.
Product Name:
UGT2B17 Polyclonal Antibody
SKU:
CAB20683
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 50-200 of human UGT2B17 (NP_001068.1).
This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the metabolism of steroids. Copy number variation in this gene is associated with susceptibility to osteoporosis.
Purification Method:
Affinity purification
Gene ID:
7367
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Immunofluorescence analysis of HepG2 cells using UGT2B17 Rabbit pAb (CAB20683) at dilution of 1:200 (40x lens). Blue: DAPI for nuclear staining.
