The TIMM22 Polyclonal Antibody (CAB20813) is a valuable tool for researchers studying the translocase of inner mitochondrial membrane 22 homolog (TIMM22) protein. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to TIMM22, this antibody enables precise detection and analysis of the protein in diverse cell types, making it an essential component for investigations in cell biology and mitochondrial research.TIMM22 is a crucial component of the mitochondrial import machinery, facilitating the transport of nuclear-encoded proteins into the mitochondrial inner membrane.
As such, understanding the function and regulation of TIMM22 is key to unraveling the complexities of mitochondrial protein import and turnover. Research into TIMM22 may offer insights into mitochondrial dysfunction-related diseases, including neurodegenerative disorders, metabolic syndromes, and aging processes.With its ability to accurately target and detect TIMM22 in various experimental settings, the TIMM22 Polyclonal Antibody is an indispensable tool for researchers aiming to delve deeper into the intricacies of mitochondrial biology and its implications in human health and disease.
Product Name:
Timm22 Polyclonal Antibody
SKU:
CAB20813
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 19-121 of mouse Timm22 (NP_062792.2).
WB,1:500 - 1:1000 IP,0.5μg-4μg antibody for 400μg-600μg extracts of whole cells
Synonyms:
Tim22; Timm22
Positive Sample:
T47D,Mouse brain,Rat testis,Rat brain
Conjugate:
Unconjugated
Cellular Localization:
mitochondrial inner membrane, mitochondrion
Calculated MW:
20kDa
Observed MW:
20kDa
Predicted to enable mitochondrion targeting sequence binding activity and protein transmembrane transporter activity. Predicted to be involved in protein insertion into mitochondrial inner membrane. Predicted to act upstream of or within protein transport. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; cardiovascular system; egg cylinder; and genitourinary system. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 43. Orthologous to human TIMM22 (translocase of inner mitochondrial membrane 22).
Purification Method:
Affinity purification
Gene ID:
56322
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using Timm22 Rabbit pAb (CAB20813) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
