| UniProt Protein Function: | Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.[provided by RefSeq, Sep 2009] |
| UniProt Code: | Q495A1 |
| NCBI GenInfo Identifier: | 121943253 |
| NCBI Gene ID: | 201633 |
| NCBI Accession: | Q495A1.1 |
| UniProt Secondary Accession: | Q495A1,Q495A3, Q5JPD8, Q6MZS2, Q8N877 |
| UniProt Related Accession: | Q495A1 |
| Molecular Weight: | 18,432 Da |
| NCBI Full Name: | T-cell immunoreceptor with Ig and ITIM domains |
| NCBI Synonym Full Names: | T cell immunoreceptor with Ig and ITIM domains |
| NCBI Official Symbol: | TIGIT |
| NCBI Official Synonym Symbols: | VSIG9; VSTM3; WUCAM |
| NCBI Protein Information: | T-cell immunoreceptor with Ig and ITIM domains |
| UniProt Protein Name: | T-cell immunoreceptor with Ig and ITIM domains |
| UniProt Synonym Protein Names: | V-set and immunoglobulin domain-containing protein 9; V-set and transmembrane domain-containing protein 3 |
| Protein Family: | T-cell immunoreceptor with Ig and ITIM domains |
| UniProt Gene Name: | TIGIT |
| UniProt Entry Name: | |
![Anti-Human TIGIT [4E1.2] In Vivo Antibody - Low Endotoxin](https://cdn11.bigcommerce.com/s-39x6lpnvxv/images/stencil/590x590/products/119999/118182/anti-human-tigit-4e1.2-in-vivo-antibody-low-endotoxin__05822__46427.1698937811.jpg?c=1 "Anti-Human TIGIT [4E1.2] In Vivo Antibody - Low Endotoxin")
