The Anti-SRP72 Antibody (CAB10899) is a valuable tool for researchers studying SRP72, a vital component of the signal recognition particle (SRP) complex involved in protein trafficking and targeting to the endoplasmic reticulum. This polyclonal antibody, raised in rabbits, has been extensively validated for use in Western blot applications with human samples, enabling researchers to detect and analyze SRP72 in various cell types.SRP72 is essential for the proper functioning of the SRP complex, which plays a crucial role in protein synthesis and cellular homeostasis. Dysregulation of SRP72 has been linked to various diseases, including neurodegenerative disorders and viral infections, making it a promising target for further research.
By utilizing the Anti-SRP72 Antibody, researchers can gain a better understanding of the molecular mechanisms involving SRP72 and its implications in disease pathology.With its high reactivity and specificity, the Anti-SRP72 Antibody offers a reliable tool for exploring SRP72 function in immunology, cancer research, and other fields of biomedical science. Researchers can leverage this antibody to uncover new insights into protein trafficking pathways and potential therapeutic targets for treating diseases associated with SRP72 dysregulation.
Product Name:
SRP72 Polyclonal Antibody
SKU:
CAB10899
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 440-544 of human SRP72 (NP_008878.3).
This gene encodes the 72 kDa subunit of the signal recognition particle (SRP), a ribonucleoprotein complex that mediates the targeting of secretory proteins to the endoplasmic reticulum (ER). The SRP complex consists of a 7S RNA and 6 protein subunits: SRP9, SRP14, SRP19, SRP54, SRP68, and SRP72, that are bound to the 7S RNA as monomers or heterodimers. SRP has at least 3 distinct functions that can be associated with the protein subunits: signal recognition, translational arrest, and ER membrane targeting by interaction with the docking protein. Mutations in this gene are associated with familial bone marrow failure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
6731
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using SRP72 Rabbit pAb (CAB10899) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
