The SMG1 Monoclonal Antibody (CAB19253) is a valuable tool for researchers studying SMG1, a protein involved in mRNA surveillance and nonsense-mediated mRNA decay. This antibody, produced in mice, specifically recognizes human SMG1 and has been validated for use in Western blot applications. By binding to the SMG1 protein, researchers can accurately detect and analyze its expression levels in a variety of cell types.SMG1 is essential for maintaining the integrity of the cellular mRNA pool by degrading aberrant transcripts and plays a crucial role in mRNA quality control mechanisms.
Dysregulation of SMG1 function has been implicated in various diseases, including neurodegenerative disorders, cancer, and genetic syndromes. Investigating the function of SMG1 is important for understanding its role in these pathologies and identifying potential therapeutic targets for intervention.This SMG1 Monoclonal Antibody provides researchers with a reliable tool for studying the function and expression of SMG1 in both normal and diseased conditions, advancing our understanding of mRNA surveillance mechanisms and their implications in human health and disease.
Product Name:
SMG1 Monoclonal Antibody
SKU:
CAB19253
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 3562-3661 of human SMG1 (Q96Q15).
This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternatively spliced transcript variants have been described, but their full-length nature has yet to be determined.
Purification Method:
Affinity purification
Gene ID:
23049
Clone Number:
ARC2417
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SMG1 antibody (CAB19253) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
