| UniProt Protein Function: | Siglec-10: a cell surface protein belonging to the immunoglobulin superfamily and the SIGLEC (sialic acid binding Ig-like lectin) family. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha2,3- or 2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Five alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13.3 |
| NCBI Summary: | SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002] |
| UniProt Code: | Q96LC7 |
| NCBI GenInfo Identifier: | 118572721 |
| NCBI Gene ID: | 89790 |
| NCBI Accession: | Q96LC7.3 |
| UniProt Secondary Accession: | Q96LC7,Q3MIR5, Q6UXI8, Q96G54, Q96LC8, A8K1I5, A8K3C7 C9JJ33, C9JM10, F8W917, |
| UniProt Related Accession: | Q96LC7 |
| Molecular Weight: | 57,486 Da |
| NCBI Full Name: | Sialic acid-binding Ig-like lectin 10 |
| NCBI Synonym Full Names: | sialic acid binding Ig like lectin 10 |
| NCBI Official Symbol: | SIGLEC10 |
| NCBI Official Synonym Symbols: | SLG2; PRO940; SIGLEC-10 |
| NCBI Protein Information: | sialic acid-binding Ig-like lectin 10 |
| UniProt Protein Name: | Sialic acid-binding Ig-like lectin 10 |
| UniProt Synonym Protein Names: | Siglec-like protein 2 |
| Protein Family: | Sialic acid-binding Ig-like lectin |
| UniProt Gene Name: | SIGLEC10 |
| UniProt Entry Name: | SIG10_HUMAN |
