The PRKCSH Polyclonal Antibody (CAB4045) is a research tool specifically designed for studying PRKCSH, a key protein involved in cellular processes such as protein folding and transport. This antibody, produced in rabbits, exhibits high reactivity towards human samples and has been validated for use in Western blot applications. By binding to the PRKCSH protein, researchers can effectively detect and analyze its presence in various cell types, making it an essential tool for investigations in molecular biology and cellular physiology.
PRKCSH, also known as protein kinase C substrate 80K-H, plays a crucial role in maintaining cellular homeostasis by facilitating proper protein folding within the endoplasmic reticulum. Dysregulation of PRKCSH has been linked to diseases such as liver cirrhosis and cystic fibrosis, highlighting its importance in biological processes. Understanding the function of PRKCSH is key to developing targeted therapies for these conditions and expanding our knowledge of protein folding mechanisms in health and disease.
Product Name:
PRKCSH Rabbit Polyclonal Antibody
SKU:
CAB4045
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 130-275 of human PRKCSH (P14314).
This gene encodes the beta-subunit of glucosidase II, an N-linked glycan-processing enzyme in the endoplasmic reticulum. The encoded protein is an acidic phosphoprotein known to be a substrate for protein kinase C. Mutations in this gene have been associated with the autosomal dominant polycystic liver disease. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
5589
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PRKCSH Rabbit pAb (CAB4045) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
