Anti-PLA2G2A Antibody (CAB19252)

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SKU:
CAB19252
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
PLA2G2A
MOM1
PLA2
PLA2B
PLA2L
PLA2S
PLAS1
sPLA2
phospholipase A2 group IIA
Frequently bought together:

Description

Product Name:PLA2G2A Rabbit mAb
Product Code:CAB19252
Size:20uL, 50uL, 100uL
Synonyms:PLA2G2A, MOM1, PLA2, PLA2B, PLA2L, PLA2S, PLAS1, sPLA2, phospholipase A2 group IIA
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human PLA2G2A.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HT-29, HepG2, DU145, Mouse liver, Mouse spleen, Mouse small intestine, Rat spleen, Rat small intestine, Rat liver
Immunogen:Recombinant protein of human PLA2G2A.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:5320
Uniprot:P14555
Cellular Location:Membrane, Peripheral membrane protein
Calculated MW:14kDa
Observed MW:15KDa
UniProt Protein Function:PLA2G2A: Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Belongs to the phospholipase A2 family.
UniProt Protein Details:

Protein type:Lipid Metabolism - arachidonic acid; Secreted, signal peptide; Vesicle; Endoplasmic reticulum; Phospholipase; EC 3.1.1.4; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - ether lipid; Lipid Metabolism - alpha-linolenic acid; Mitochondrial; Secreted; Lipid Metabolism - linoleic acid

Chromosomal Location of Human Ortholog: 1p35

Cellular Component: extracellular space; endoplasmic reticulum membrane; mitochondrion; endoplasmic reticulum; extracellular region; secretory granule

Molecular Function:phospholipase A2 activity; calcium-dependent phospholipase A2 activity; phospholipid binding; calcium ion binding

Biological Process: defense response to Gram-positive bacterium; phosphatidic acid metabolic process; somatic stem cell maintenance; phospholipid metabolic process; glycerophospholipid biosynthetic process; phosphatidic acid biosynthetic process; lipid catabolic process; positive regulation of inflammatory response; negative regulation of epithelial cell proliferation

Disease: Colorectal Cancer

NCBI Summary:The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009]
UniProt Code:P14555
NCBI GenInfo Identifier:129483
NCBI Gene ID:5320
NCBI Accession:P14555.2
UniProt Secondary Accession:P14555,Q6DN24, Q6IBD9, Q9UCD2, A8K5I7,
UniProt Related Accession:P14555
Molecular Weight:144
NCBI Full Name:Phospholipase A2, membrane associated
NCBI Synonym Full Names:phospholipase A2, group IIA (platelets, synovial fluid)
NCBI Official Symbol:PLA2G2A  
NCBI Official Synonym Symbols:MOM1; PLA2; PLA2B; PLA2L; PLA2S; PLAS1; sPLA2  
NCBI Protein Information:phospholipase A2, membrane associated; NPS-PLA2; GIIC sPLA2; group IIA phospholipase A2; phosphatidylcholine 2-acylhydrolase 2A; non-pancreatic secretory phospholipase A2
UniProt Protein Name:Phospholipase A2, membrane associated
UniProt Synonym Protein Names:GIIC sPLA2; Group IIA phospholipase A2; Non-pancreatic secretory phospholipase A2; NPS-PLA2; Phosphatidylcholine 2-acylhydrolase 2A
Protein Family:Phospholipase
UniProt Gene Name:PLA2G2A  
UniProt Entry Name:PA2GA_HUMAN

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